M
Marc S. Greenblatt
Researcher at University of Vermont
Publications - 85
Citations - 12337
Marc S. Greenblatt is an academic researcher from University of Vermont. The author has contributed to research in topics: Cancer & Human Variome Project. The author has an hindex of 35, co-authored 77 publications receiving 11100 citations. Previous affiliations of Marc S. Greenblatt include National Institutes of Health.
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Journal Article
Mutations in the p53 Tumor Suppressor Gene: Clues to Cancer Etiology and Molecular Pathogenesis
TL;DR: The p53 tumor suppressor gene has become a paradigm in cancer research because it is commonly mutated in human cancer and the spectrum of p53 mutations in these cancers is providing clues to the etiology and molecular pathogenesis of neoplasia as discussed by the authors.
Journal ArticleDOI
HGVS Recommendations for the Description of Sequence Variants: 2016 Update
Johan T. den Dunnen,Raymond Dalgleish,Donna Maglott,Reece K. Hart,Marc S. Greenblatt,Jean McGowan-Jordan,Anne-Françoise Roux,Timothy D. Smith,Stylianos E. Antonarakis,Peter E.M. Taschner +9 more
TL;DR: The current recommendations, HGVS version 15.11, are presented, and briefly summarize the changes that were made since the 2000 publication, with most focus on removing inconsistencies and tightening definitions allowing automatic data processing.
Journal Article
Database of p53 gene somatic mutations in human tumors and cell lines.
Monica Hollstein,K. Rice,Marc S. Greenblatt,Thierry Soussi,R. Fuchs,Therese Sørlie,Eivind Hovig,Birgitte Smith-Sørensen,Ruggero Montesano,Chris Harris +9 more
TL;DR: A data base is described in which over 2,500 mutations in the p53 gene of human tumors and tumor cell lines are compiled from a systematic search of reports published before 1 January 1994.
Journal ArticleDOI
Sequence variant classification and reporting: recommendations for improving the interpretation of cancer susceptibility genetic test results
Sharon E. Plon,Diana Eccles,Douglas F. Easton,William D. Foulkes,Maurizio Genuardi,Marc S. Greenblatt,Frans B. L. Hogervorst,Nicoline Hoogerbrugge,Amanda B. Spurdle,Sean V. Tavtigian +9 more
TL;DR: The current state of sequence‐based genetic testing is reviewed, other standardized reporting systems used in oncology are described, and a standardized classification system for application to sequence-based results for cancer predisposition genes is proposed.
Journal ArticleDOI
Somatic point mutations in the p53 gene of human tumors and cell lines: updated compilation.
Monica Hollstein,Benny Shomer,Marc S. Greenblatt,Thierry Soussi,Eivind Hovig,Ruggero Montesano,Chris Harris +6 more
TL;DR: This report describes the criteria for inclusion of data in this database, a description of the current format and a brief discussion of theCurrent relevance of p53 mutation analysis to clinical and biological questions.