Sheri M. Eaton

TL;DR: It is proposed that vaccination induces IL-17-producing CD4+ T cells that populate the lung and, after challenge, trigger the production of chemokines that recruit CD4- T cells producing interferon-γ, which ultimately restrict bacterial growth.

TL;DR: Two populations of “effector” B cells (Be1 and Be2) are identified that produce distinct patterns of cytokines depending on the cytokine environment in which the cells were stimulated during their primary encounter with antigen and T cells, suggesting that B cells may regulate immune responses to infectious pathogens through their production of cytokine.

TL;DR: It is shown that IL-6 is sufficient and necessary to induce IL-21 production by naive and memory CD4+ T cells upon T cell receptor stimulation and could be a potential coadjuvant to enhance humoral immunity.

TL;DR: Age-related reductions in the cognate helper function of CD4 T cells contribute significantly to defects in humoral responses observed in aged individuals, and a novel adoptive transfer model is used to compare identical numbers of antigen-specific naive T cells from young and aged TCR transgenic donors.

TL;DR: The results indicate that it is the age of the naive T cell when it first encounters antigen, rather than the age when it reencounters antigen, that is critical for good memory CD4 T cell function.