J
Jennifer Flanagan
Researcher at University of California, San Francisco
Publications - 8
Citations - 430
Jennifer Flanagan is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Phosphatase & PTEN. The author has an hindex of 7, co-authored 8 publications receiving 338 citations. Previous affiliations of Jennifer Flanagan include University of California, Davis.
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Journal ArticleDOI
RAS-MAPK dependence underlies a rational polytherapy strategy in EML4-ALK-positive lung cancer.
Gorjan Hrustanovic,Victor Olivas,Evangelos Pazarentzos,Asmin Tulpule,Saurabh Asthana,Collin M. Blakely,Ross A. Okimoto,Luping Lin,Dana S. Neel,Amit J. Sabnis,Jennifer Flanagan,Elton Chan,Marileila Varella-Garcia,Dara L. Aisner,Aria Vaishnavi,Sai-Hong Ignatius Ou,Eric A. Collisson,Eiki Ichihara,Philip C. Mack,Christine M. Lovly,Niki Karachaliou,Rafael Rosell,Jonathan W. Riess,Robert C. Doebele,Trever G. Bivona +24 more
TL;DR: It is demonstrated in models of lung adenocarcinoma harboring the oncogenic fusion of ALK and EML4 that the GTPase RAS–mitogen-activated protein kinase (MAPK) pathway, but not other known ALK effectors, is required for tumor-cell survival.
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Inactivation of Capicua drives cancer metastasis
Ross A. Okimoto,Frank Breitenbuecher,Victor Olivas,Wei Wu,Beatrice Gini,Matan Hofree,Saurabh Asthana,Gorjan Hrustanovic,Jennifer Flanagan,Asmin Tulpule,Collin M. Blakely,Henry J. Haringsma,Andrew Simmons,Kyle Gowen,James Suh,Vincent A. Miller,Siraj M. Ali,Martin Schuler,Trever G. Bivona +18 more
TL;DR: The development of an in vivo spontaneous lung cancer metastasis model shows that the developmentally regulated transcriptional repressor Capicua (CIC) suppresses invasion and metastasis, highlighting new anti-metastatic strategies that could potentially improve patient outcomes.
Journal ArticleDOI
Combined chemical–genetic approach identifies cytosolic HSP70 dependence in rhabdomyosarcoma
Amit J. Sabnis,Christopher J. Guerriero,Victor Olivas,Anin Sayana,Jonathan Shue,Jennifer Flanagan,Saurabh Asthana,Adrienne W. Paton,James C. Paton,Jason E. Gestwicki,Peter Walter,Jonathan S. Weissman,Peter Wipf,Jeffrey L. Brodsky,Trever G. Bivona +14 more
TL;DR: It is shown that human rhabdomyosarcoma (RMS) cells, but not several other cancer cell types, depend upon heat-shock protein 70 kDA (HSP70) for survival, and the cytosolic HSP70–UPR axis is identified as an unexpected regulator of RMS pathogenesis.
Journal ArticleDOI
Microbial Community Succession and Nutrient Cycling Responses following Perturbations of Experimental Saltwater Aquaria.
Holly M. Bik,Alexandra Alexiev,Sabreen K. Aulakh,Lakshmi Bharadwaj,Jennifer Flanagan,John M. Haggerty,Sarah M. Hird,Sarah M. Hird,Guillaume Jospin,Jenna M. Lang,Laura A. Sauder,Josh D. Neufeld,Andrew Shaver,Akshay Sethi,Jonathan A. Eisen,David A. Coil +15 more
TL;DR: The results demonstrate that aquarium perturbations have a substantial impact on microbial community profiles of aquarium water and sediment and that the addition of live rocks improves nutrient cycling by shifting aquarium communities toward a more typical saltwater assemblage of microbial taxa.
Journal ArticleDOI
Synthetic Essentiality of Metabolic Regulator PDHK1 in PTEN-Deficient Cells and Cancers.
Nilanjana Chatterjee,Evangelos Pazarentzos,Manasi K. Mayekar,Philippe Gui,David V. Allegakoen,Gorjan Hrustanovic,Victor Olivas,Luping Lin,Erik Verschueren,Erik Verschueren,Erik Verschueren,Jeffrey R. Johnson,Jeffrey R. Johnson,Jeffrey R. Johnson,Matan Hofree,Jenny Jiacheng Yan,Billy W. Newton,Billy W. Newton,Billy W. Newton,John Von Dollen,John Von Dollen,John Von Dollen,Charles H. Earnshaw,Jennifer Flanagan,Elton Chan,Saurabh Asthana,Trey Ideker,Wei Wu,Junji Suzuki,Benjamin A Barad,Yuriy Kirichok,James S. Fraser,William A. Weiss,Nevan J. Krogan,Nevan J. Krogan,Nevan J. Krogan,Asmin Tulpule,Amit J. Sabnis,Trever G. Bivona +38 more
TL;DR: It is reported that the metabolic regulator pyruvate dehydrogenase kinase1 (PDHK1) is a synthetic-essential gene in PTEN-deficient cancer and normal cells.