Jennifer H. Barnett

TL;DR: Despite initially promising results, the COMT Val158/108Met polymorphism appears to have little if any association with cognitive function and publication bias may hamper attempts to understand the genetic basis of psychological functions and psychiatric disorders.

TL;DR: Genomewide association analysis, which has successfully identified susceptibility genes for a variety of complex disorders, has begun to implicate specific genes for bipolar disorder (DGKH, CACNA1C, ANK3); the polygenicity of the disorder means that very large samples will be needed to detect the modest effect loci that likely contribute to bipolar disorder.

TL;DR: Substance misuse is present in the majority of people with first-episode psychosis and has major implications for management and the association between age at first substance use and first psychotic symptoms has public health implications.

TL;DR: Strong associations between premorbid IQ and risk for schizophrenia, and age of illness onset argue for a widespread neurodevelopmental contribution to schizophrenia that operates across the entire range of intellectual ability.

TL;DR: There is small but significant relationship between Val158Met genotype and executive function in healthy individuals but not in schizophrenia, and it is suggested that Val and Met alleles are codominant in their effects on cognition.