J
Jennifer L. Uhrlaub
Researcher at University of Arizona
Publications - 48
Citations - 2453
Jennifer L. Uhrlaub is an academic researcher from University of Arizona. The author has contributed to research in topics: Immune system & Cytotoxic T cell. The author has an hindex of 20, co-authored 40 publications receiving 1851 citations. Previous affiliations of Jennifer L. Uhrlaub include Johns Hopkins University School of Medicine & Oregon National Primate Research Center.
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Journal ArticleDOI
Orthogonal SARS-CoV-2 Serological Assays Enable Surveillance of Low-Prevalence Communities and Reveal Durable Humoral Immunity.
Tyler J. Ripperger,Jennifer L. Uhrlaub,Makiko Watanabe,Rachel O.L. Wong,Rachel O.L. Wong,Yvonne Castaneda,Hannah A. Pizzato,Hannah A. Pizzato,Mallory R. Thompson,Christine M. Bradshaw,Craig Weinkauf,Christian Bime,Heidi Erickson,Kenneth S. Knox,Billie Bixby,Sairam Parthasarathy,Sachin Chaudhary,Bhupinder Natt,Elaine Cristan,Tammer El Aini,Franz Rischard,Janet Campion,Madhav Chopra,Michael Insel,Afshin Sam,James Knepler,Andrew P. Capaldi,Catherine M. Spier,Michael D. Dake,Taylor Edwards,Matthew E. Kaplan,Serena Jain Scott,Cameron Hypes,Jarrod Mosier,David T. Harris,Bonnie LaFleur,Ryan Sprissler,Janko Nikolich-Žugich,Deepta Bhattacharya +38 more
TL;DR: It is concluded that neutralizing antibodies are stably produced for at least 5-7 months after SARS-CoV-2 infection.
Journal ArticleDOI
Aging and Cytomegalovirus Infection Differentially and Jointly Affect Distinct Circulating T Cell Subsets in Humans
Anne M. Wertheimer,Michael S. Bennett,Byung Park,Jennifer L. Uhrlaub,Carmine Martinez,Vesna Pulko,Noreen Currier,Dragana Nikolich-Žugich,Jeffrey Kaye,Janko Nikolich-Žugich +9 more
TL;DR: It is found that aging correlated strictly to an absolute loss of naive CD8, but not CD4, T cells but, contrary to many reports, did not lead to an increase in memory T cell numbers, suggesting that efficacy of viral control over time may determine the magnitude of CMV impact upon T cell memory, and perhaps upon immune defense.
Journal ArticleDOI
Neuroprotective and anti-human immunodeficiency virus activity of minocycline
M. Christine Zink,Jennifer L. Uhrlaub,Jesse B. DeWitt,Tauni Voelker,Brandon T. Bullock,Joseph L. Mankowski,Patrick M. Tarwater,Janice E. Clements,Sheila A. Barber +8 more
TL;DR: Minocycline reduced the severity of encephalitis, suppressed viral load in the brain, and decreased the expression of CNS inflammatory markers in this experimental SIV model of HIV CNS disease, suggesting that minocyCline, a safe, inexpensive, and readily available antibiotic should be investigated as an anti-HIV therapeutic.
Journal ArticleDOI
West Nile virus-specific CD4 T cells exhibit direct antiviral cytokine secretion and cytotoxicity and are sufficient for antiviral protection.
James D. Brien,Jennifer L. Uhrlaub,Jennifer L. Uhrlaub,Janko Nikolich-Žugich,Janko Nikolich-Žugich +4 more
TL;DR: Evidence is provided for the direct antiviral activity of CD4 T cells that functions to protect the host from WNV encephalitis and peptide vaccination using CD4 epitopes conferred protection against lethal WNV infection in immunocompetent mice.
Journal ArticleDOI
Key role of T cell defects in age-related vulnerability to West Nile virus.
James D. Brien,Jennifer L. Uhrlaub,Jennifer L. Uhrlaub,Alec J. Hirsch,Clayton A. Wiley,Janko Nikolich-Zugich,Janko Nikolich-Zugich +6 more
TL;DR: It is demonstrated that death correlates with increased viral titers in the brain and that this loss of virus control with age was the result of defects in the CD4 and CD8 T cell response against WNV, identifying potential targets for immunomodulation and treatment to combat lethal WNV infection in the elderly.