J
John A. Curtin
Researcher at Manchester Academic Health Science Centre
Publications - 52
Citations - 8669
John A. Curtin is an academic researcher from Manchester Academic Health Science Centre. The author has contributed to research in topics: Genome-wide association study & Asthma. The author has an hindex of 28, co-authored 44 publications receiving 7597 citations. Previous affiliations of John A. Curtin include GlaxoSmithKline & University of California, San Francisco.
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Journal ArticleDOI
Distinct Sets of Genetic Alterations in Melanoma
John A. Curtin,Jane Fridlyand,Toshiro Kageshita,Hetal N. Patel,Klaus J. Busam,Heinz Kutzner,Kwang Hyun Cho,Setsuya Aiba,Eva B. Bröcker,Philip E. LeBoit,Daniel Pinkel,Boris C. Bastian +11 more
TL;DR: The genetic alterations identified in melanoma at different sites and with different levels of sun exposure indicate that there are distinct genetic pathways in the development of melanoma and implicate CDK4 and CCND1 as independent oncogenes in melanomas without mutations in BRAF or N-RAS.
Journal ArticleDOI
Somatic Activation of KIT in Distinct Subtypes of Melanoma
TL;DR: Imatinib may offer an immediate therapeutic benefit for a significant proportion of the global melanoma burden because the majority of the KIT mutations found in melanoma also occur in imatinib-responsive cancers of other types.
Journal ArticleDOI
Mutation of Celsr1 disrupts planar polarity of inner ear hair cells and causes severe neural tube defects in the mouse.
John A. Curtin,Elizabeth Quint,Vicky Tsipouri,Ruth M. Arkell,Bruce Cattanach,Andrew J. Copp,Deborah J. Henderson,Nigel K. Spurr,Philip Stanier,Elizabeth M. C. Fisher,Patrick M. Nolan,Karen P. Steel,Steve D.M. Brown,Ian C. Gray,Jennifer N. Murdoch +14 more
TL;DR: The identification of mouse mutants of Celsr1 provides the first evidence for the function of the CelsR family in planar cell polarity in mammals and further supports the involvement of a planarcell polarity pathway in vertebrate neurulation.
Journal ArticleDOI
Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis
Lavinia Paternoster,Marie Standl,Johannes Waage,H. Baurecht,Melanie Hotze,David P. Strachan,John A. Curtin,Klaus Bønnelykke,Chao Tian,Atsushi Takahashi,Jorge Esparza-Gordillo,Alexessander Couto Alves,Jacob P. Thyssen,Herman T. den Dekker,Manuel A. R. Ferreira,Elisabeth Altmaier,Patrick M. A. Sleiman,Patrick M. A. Sleiman,Feng Li Xiao,Juan R. González,Juan R. González,Ingo Marenholz,Birgit Kalb,Maria Pino-Yanes,Maria Pino-Yanes,Cheng-Jian Xu,Lisbeth Carstensen,Maria M. Groen-Blokhuis,Cristina Venturini,Craig E. Pennell,Sheila J. Barton,Albert M. Levin,Ivan Curjuric,Ivan Curjuric,Mariona Bustamante,Eskil Kreiner-Møller,Gabrielle A. Lockett,Jonas Bacelis,Supinda Bunyavanich,Rachel A. Myers,Anja Matanovic,Ashok Kumar,Joyce Y. Tung,Tomomitsu Hirota,Michiaki Kubo,Wendy L. McArdle,A. John Henderson,John P. Kemp,John P. Kemp,Jie Zheng,George Davey Smith,Franz Rueschendorf,Anja Bauerfeind,Min Ae Lee-Kirsch,Andreas Arnold,Georg Homuth,Carsten Oliver Schmidt,Elisabeth Mangold,Sven Cichon,Thomas Keil,Elke Rodriguez,Annette Peters,Andre Franke,Wolfgang Lieb,Natalija Novak,Regina Foelster-Holst,Momoko Horikoshi,Juha Pekkanen,Sylvain Sebert,Lise Lotte N. Husemoen,Niels Grarup,Johan C. de Jongste,Fernando Rivadeneira,Albert Hofman,Vincent W. V. Jaddoe,Suzanne G.M.A. Pasmans,Niels J. Elbert,André G. Uitterlinden,Guy B. Marks,Philip J. Thompson,Melanie C. Matheson,Colin F. Robertson,Janina S. Ried,Jin Li,Xian Bo Zuo,X. Zheng,Xianyong Yin,Liangdan Sun,Maeve A. McAleer,Grainne M. O'Regan,Caoimhe M. R. Fahy,Linda E. Campbell,Milan Macek,Michael Kurek,Donglei Hu,Celeste Eng,Dirkje S. Postma,Bjarke Feenstra,Frank Geller,Jouke-Jan Hottenga,Christel M. Middeldorp,Pirro G. Hysi,Veronique Bataille,Tim D. Spector,Carla M. T. Tiesler,Elisabeth Thiering,Badri Pahukasahasram,James J. Yang,Medea Imboden,Scott Huntsman,Natalia Vilor-Tejedor,Caroline L Relton,Ronny Myhre,Wenche Nystad,Adnan Custovic,Scott T. Weiss,Deborah A. Meyers,Cilla Soederhaell,Erik Melén,Carole Ober,Benjamin A. Raby,Angela Simpson,Bo Jacobsson,John W. Holloway,Hans Bisgaard,Jordi Sunyer,Nicole Probst-Hensch,L. Keoki Williams,Keith M. Godfrey,Carol A. Wang,Dorret I. Boomsma,Mads Melbye,Gerard H. Koppelman,Deborah Jarvis,W.H. Irwin McLean,Alan D. Irvine,Xuejun Zhang,Hakon Hakonarson,Christian Gieger,Esteban G. Burchard,Nicholas G. Martin,Liesbeth Duijts,Allan Linneberg,Marjo-Riitta Järvelin,Markus M. Noethen,Susanne Lau,Norbert Huebner,Young-Ae Lee,Mayumi Tamari,David A. Hinds,Daniel Glass,Sara J. Brown,Joachim Heinrich,David M. Evans,Stephan Weidinger +154 more
TL;DR: This paper performed a meta-analysis of >15 million genetic variants in 21,399 cases and 95,464 controls from populations of European, African, Japanese and Latino ancestry, followed by replication in 32,059 cases and 228,628 controls from 18 studies.
Journal ArticleDOI
Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks
Florence Demenais,Florence Demenais,Patricia Margaritte-Jeannin,Patricia Margaritte-Jeannin,Kathleen C. Barnes,William O.C.M. Cookson,Janine Altmüller,Wei Ang,R. Graham Barr,Terri H. Beaty,Allan B. Becker,John Beilby,Hans Bisgaard,Unnur S. Bjornsdottir,Eugene R. Bleecker,Klaus Bønnelykke,Dorret I. Boomsma,Emmanuelle Bouzigon,Emmanuelle Bouzigon,Christopher E. Brightling,Myriam Brossard,Myriam Brossard,Guy Brusselle,Guy Brusselle,Esteban G. Burchard,Kristin M. Burkart,Andrew Bush,Andrew Bush,Moira Chan-Yeung,Kian Fan Chung,Kian Fan Chung,Alexessander Couto Alves,John A. Curtin,Adnan Custovic,Denise Daley,Johan C. de Jongste,Blanca E. Del-Rio-Navarro,Kathleen M. Donohue,Liesbeth Duijts,Celeste Eng,Johan G. Eriksson,Martin Farrall,Yuliya Fedorova,Bjarke Feenstra,Manuel A. R. Ferreira,Maxim B. Freidin,Zofia K. Z. Gajdos,Zofia K. Z. Gajdos,Jim Gauderman,Ulrike Gehring,Frank Geller,Jon Genuneit,Sina A. Gharib,Frank D. Gilliland,Raquel Granell,Penelope E. Graves,Daniel F. Gudbjartsson,Daniel F. Gudbjartsson,Tari Haahtela,Susan R. Heckbert,Dick Heederik,Joachim Heinrich,Markku Heliövaara,John Henderson,Blanca E. Himes,Hiroshi Hirose,Joel N. Hirschhorn,Joel N. Hirschhorn,Albert Hofman,Albert Hofman,Patrick G. Holt,Jouke J. Hottenga,Thomas J. Hudson,Thomas J. Hudson,Jennie Hui,Medea Imboden,Medea Imboden,Vladimir P. Ivanov,Vincent W. V. Jaddoe,Alan James,Alan James,Christer Janson,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,Deborah Jarvis,Graham Jones,Ingileif Jonsdottir,Ingileif Jonsdottir,Pekka Jousilahti,Michael Kabesch,Mika Kähönen,David B. Kantor,A. S. Karunas,Elza Khusnutdinova,Gerard H. Koppelman,Anita L. Kozyrskyj,Eskil Kreiner,Michiaki Kubo,Rajesh Kumar,Rajesh Kumar,Ashok Kumar,Ashok Kumar,Ashok Kumar,Mikko Kuokkanen,Mikko Kuokkanen,Lies Lahousse,Lies Lahousse,Tarja Laitinen,Catherine Laprise,Mark Lathrop,Susanne Lau,Young-Ae Lee,Young-Ae Lee,Terho Lehtimäki,Sébastien Letort,Sébastien Letort,Albert M. Levin,Guo Li,Liming Liang,Laura R. Loehr,Stephanie J. London,Daan W. Loth,Ani Manichaikul,Ingo Marenholz,Ingo Marenholz,Fernando J. Martinez,Melanie C. Matheson,Rasika A. Mathias,Kenji Matsumoto,Hamdi Mbarek,Wendy L. McArdle,Mads Melbye,Mads Melbye,Mads Melbye,Erik Melén,Erik Melén,Deborah A. Meyers,Sven Michel,Hamida Mohamdi,Hamida Mohamdi,Arthur W. Musk,Arthur W. Musk,Rachel A. Myers,Maartje A.E. Nieuwenhuis,Emiko Noguchi,George T. O'Connor,George T. O'Connor,Ludmila M. Ogorodova,Cameron D. Palmer,Cameron D. Palmer,Aarno Palotie,Aarno Palotie,Aarno Palotie,Julie E. Park,Craig E. Pennell,Göran Pershagen,Göran Pershagen,Alexey Polonikov,Dirkje S. Postma,Nicole Probst-Hensch,Nicole Probst-Hensch,V. P. Puzyrev,Benjamin A. Raby,Olli T. Raitakari,Adaikalavan Ramasamy,Adaikalavan Ramasamy,Stephen S. Rich,Colin F. Robertson,Isabelle Romieu,Muhammad T. Salam,Veikko Salomaa,Vivi Schlünssen,Robert A. Scott,P. A. Selivanova,Torben Sigsgaard,Angela Simpson,Valérie Siroux,Valérie Siroux,Lewis J. Smith,Maria Solodilova,Marie Standl,Kari Stefansson,Kari Stefansson,David P. Strachan,Bruno H. Stricker,Atsushi Takahashi,Philip J. Thompson,Gudmar Thorleifsson,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Carla M. T. Tiesler,Dara G. Torgerson,Tatsuhiko Tsunoda,André G. Uitterlinden,Ralf J. P. van der Valk,Amaury Vaysse,Amaury Vaysse,Sailaja Vedantam,Sailaja Vedantam,Andrea von Berg,Erika von Mutius,Judith M. Vonk,Johannes Waage,Nicholas J. Wareham,Scott T. Weiss,Wendy B. White,Magnus Wickman,Magnus Wickman,Elisabeth Widen,Gonneke Willemsen,L. Keoki Williams,Inge M. Wouters,James J. Yang,Jing Hua Zhao,Miriam F. Moffatt,Carole Ober,Dan L. Nicolae +216 more
TL;DR: A meta-analysis of GWAS studies for asthma from multiancestral cohorts identifies five new loci and finds that the asthma-associated loci are enriched near enhancer marks in immune cells, suggesting a major role of these loci in the regulation of immunologically related mechanisms.