R
Ruth M. Arkell
Researcher at Australian National University
Publications - 64
Citations - 4327
Ruth M. Arkell is an academic researcher from Australian National University. The author has contributed to research in topics: Gene & ZIC2. The author has an hindex of 31, co-authored 63 publications receiving 4045 citations. Previous affiliations of Ruth M. Arkell include National Institute for Medical Research & Imperial College London.
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Journal ArticleDOI
A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse.
Patrick M. Nolan,Josephine Peters,Mark A. Strivens,Derek C. Rogers,Jim J. Hagan,Nigel K. Spurr,Ian C. Gray,Lucie Vizor,D Brooker,E Whitehill,R Washbourne,Tertius Hough,Simon Greenaway,M Hewitt,Xue Zhong Liu,Stefan L. McCormack,K Pickford,R Selley,Christine A. Wells,Zuzanna Tymowska-Lalanne,P. Roby,Peter H. Glenister,C Thornton,Caroline Thaung,J A Stevenson,Ruth M. Arkell,Philomena Mburu,Rachel E. Hardisty,Amy E. Kiernan,Alexandra Erven,Karen P. Steel,Stéphanie Voegeling,Jean-Louis Guénet,Carole D. Nickols,R Sadri,M Nasse,Adrian M. Isaacs,Kay E. Davies,M Browne,Elizabeth M. C. Fisher,Joanne E. Martin,Sohaila Rastan,Steve D.M. Brown,Jackie Hunter +43 more
TL;DR: A genome-wide, phenotype-driven screen for dominant mutations in the mouse is undertaken, which has led to a substantial increase in themouse mutant resource and represents a first step towards systematic studies of gene function in mammalian genetics.
Journal ArticleDOI
Mutation of Celsr1 disrupts planar polarity of inner ear hair cells and causes severe neural tube defects in the mouse.
John A. Curtin,Elizabeth Quint,Vicky Tsipouri,Ruth M. Arkell,Bruce Cattanach,Andrew J. Copp,Deborah J. Henderson,Nigel K. Spurr,Philip Stanier,Elizabeth M. C. Fisher,Patrick M. Nolan,Karen P. Steel,Steve D.M. Brown,Ian C. Gray,Jennifer N. Murdoch +14 more
TL;DR: The identification of mouse mutants of Celsr1 provides the first evidence for the function of the CelsR family in planar cell polarity in mammals and further supports the involvement of a planarcell polarity pathway in vertebrate neurulation.
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Disruption of scribble (Scrb1) causes severe neural tube defects in the circletail mouse
Jennifer N. Murdoch,Deborah J. Henderson,Kit Doudney,Carles Gaston-Massuet,Helen M. Phillips,C Paternotte,Ruth M. Arkell,Philip Stanier,Andrew J. Copp +8 more
TL;DR: The identification of the Crc gene further defines the nature of the genetic pathway required for the initiation of neural tube closure and provides an important new candidate that may be implicated in the aetiology of human NTDs.
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An N-ethyl-N-nitrosourea screen for genes involved in variegation in the mouse
Marnie E. Blewitt,Nicola Vickaryous,Sarah J. Hemley,Alyson Ashe,Timothy J. C. Bruxner,Jost I Preis,Ruth M. Arkell,Emma Whitelaw +7 more
TL;DR: The findings raise the possibility that the presence or absence of the X chromosome in mammals affects the establishment of the epigenetic state at autosomal loci by acting as a sink for proteins involved in gene silencing.
Journal ArticleDOI
Loss of Atrx Affects Trophoblast Development and the Pattern of X-Inactivation in Extraembryonic Tissues
David Garrick,Jackie A Sharpe,Ruth M. Arkell,Lorraine Dobbie,Andrew J.H. Smith,William G. Wood,Douglas R. Higgs,Richard J. Gibbons +7 more
TL;DR: An unexpected, specific, and essential role for Atrx in the development of the murine trophoblast is demonstrated and an example of escape from imprinted X chromosome inactivation is presented.