Jennifer Nielsen Kahn

TL;DR: A Candida krusei strain from a patient with acute myelogenous leukemia that displayed reduced susceptibility to echinocandin drugs contained a heterozygous mutation, T2080K, in FKS1, which altered the sensitivity of glucan synthase to Echinocander drugs, consistent with a common mechanism for echinOCandin resistance in Candida spp.

TL;DR: Parnafungin displays potent and broad spectrum activity against diverse, clinically relevant fungal pathogens and reduces fungal burden in a murine model of disseminated candidiasis, and mechanism-of-action determination of crude fermentation extracts by chemical-genetic profiling brings a powerful strategy to natural-product-based drug discovery.

TL;DR: It is demonstrated that caspofungin inhibits β-d-1,3 glucan synthesis and reduces in vitro growth of clinical isolates from the genera Alternaria, Curvularia, Scedosporium, Acremonium, Bipolaris, and Trichoderma.

TL;DR: The results establish Mcd4 as a promising antifungal target and confirm the GPI cell wall anchor synthesis pathway as aPromising antif fungus target area by demonstrating that effects of inhibiting it are more general than previously recognized.

TL;DR: The production of sordarin is a trait more frequently associated to members of the Xylariales than to any other fungal order, and it was found that sordarins were the most frequently found compounds in the class.