Fred Racine

TL;DR: Platencin shows potent in vivo efficacy without any observed toxicity, emphasizing the fact that more antibiotics with novel structures and new modes of action can be discovered by using this antisense differential sensitivity whole-cell screening paradigm.

TL;DR: The data provided a molecular basis for neutralization by this clinically important antibody and are consistent with a model wherein a single molecule of bezlotoxumab neutralizes TcdB by binding via its two Fab regions to two epitopes within the N-terminal half of the TCDB CROP domain, partially blocking the carbohydrate binding pockets of the toxin and preventing toxin binding to host cells.

TL;DR: It is demonstrated that caspofungin inhibits β-d-1,3 glucan synthesis and reduces in vitro growth of clinical isolates from the genera Alternaria, Curvularia, Scedosporium, Acremonium, Bipolaris, and Trichoderma.

TL;DR: IMI/REL exhibited potential in the treatment of carbapenem-resistant P. aeruginosa infections, with the exception of isolates encoding class B, some GES alleles, and class D carbs, and no class D enzymes were detected.

TL;DR: Combined with in vitro neutralization data, epitope modeling will enhance the ability to predict the coverage of new and emerging strains by actoxumab-bezlotoxumAB in the clinic.