J
Jeou-Yuan Chen
Researcher at Academia Sinica
Publications - 60
Citations - 2786
Jeou-Yuan Chen is an academic researcher from Academia Sinica. The author has contributed to research in topics: Cancer & Gene. The author has an hindex of 30, co-authored 59 publications receiving 2611 citations. Previous affiliations of Jeou-Yuan Chen include National Taiwan Normal University & National Taiwan Ocean University.
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Journal ArticleDOI
Human semaphorins A(V) and IV reside in the 3p21.3 small cell lung cancer deletion region and demonstrate distinct expression patterns.
Yoshitaka Sekido,Scott Bader,Scott Bader,Farida Latif,Jeou-Yuan Chen,Jeou-Yuan Chen,Fuh Mei Duh,Ming Hui Wei,Joseph P. Albanesi,Cheng Chi Lee,Michael I. Lerman,John D. Minna +11 more
TL;DR: The identified two additional members of the human semaphorin family are identified in chromosome region 3p21.3, where several small cell lung cancer (SCLC) cell lines exhibit homozygous deletions indicative of a tumor suppressor gene.
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Acetylation and activation of STAT3 mediated by nuclear translocation of CD44
TL;DR: A novel function for CD44 in transcriptional modulation through nuclear translocation of the internalized CD44 and complex formation with transcription factors is described, leading to cell fate change through transcriptional reprogramming.
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Osteopontin Promotes Integrin Activation through Outside-In and Inside-Out Mechanisms: OPN-CD44V Interaction Enhances Survival in Gastrointestinal Cancer Cells
TL;DR: It is shown that OPN-CD44(V) interaction promotes ECM-derived survival signal mediated through integrin activation, which may play an important role in the pathogenic development and progression of gastric cancer.
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Immobilized metal affinity chromatography revisited: pH/acid control toward high selectivity in phosphoproteomics.
Chia-Feng Tsai,Yi-Ting Wang,Yet-Ran Chen,Chen-Yu Lai,Pei-Yi Lin,Kuan-Ting Pan,Jeou-Yuan Chen,Kay-Hooi Khoo,Yu-Ju Chen +8 more
TL;DR: This pH/acid-controlled IMAC procedure provides higher specificity than any other one-step IMAC purification procedure and can be adapted to other solid supports, fully automated or manual, for large-scale identification of the vastly under-explored phosphoproteome.
Journal Article
Human lung cancer cell lines exhibit resistance to retinoic acid treatment
Joseph Geradts,Jeou-Yuan Chen,Edward K. Russell,James R. Yankaskas,Luis Nieves,John D. Minna +5 more
TL;DR: Alarms of the RAR-beta system are common in human lung cancer cell lines, and no abnormalities in Rar-alpha gene structure or expression were identified by Southern and Northern blot analysis.