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Jeou-Yuan Chen

Researcher at Academia Sinica

Publications -  60
Citations -  2786

Jeou-Yuan Chen is an academic researcher from Academia Sinica. The author has contributed to research in topics: Cancer & Gene. The author has an hindex of 30, co-authored 59 publications receiving 2611 citations. Previous affiliations of Jeou-Yuan Chen include National Taiwan Normal University & National Taiwan Ocean University.

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Human semaphorins A(V) and IV reside in the 3p21.3 small cell lung cancer deletion region and demonstrate distinct expression patterns.

TL;DR: The identified two additional members of the human semaphorin family are identified in chromosome region 3p21.3, where several small cell lung cancer (SCLC) cell lines exhibit homozygous deletions indicative of a tumor suppressor gene.
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Acetylation and activation of STAT3 mediated by nuclear translocation of CD44

TL;DR: A novel function for CD44 in transcriptional modulation through nuclear translocation of the internalized CD44 and complex formation with transcription factors is described, leading to cell fate change through transcriptional reprogramming.
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Osteopontin Promotes Integrin Activation through Outside-In and Inside-Out Mechanisms: OPN-CD44V Interaction Enhances Survival in Gastrointestinal Cancer Cells

TL;DR: It is shown that OPN-CD44(V) interaction promotes ECM-derived survival signal mediated through integrin activation, which may play an important role in the pathogenic development and progression of gastric cancer.
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Immobilized metal affinity chromatography revisited: pH/acid control toward high selectivity in phosphoproteomics.

TL;DR: This pH/acid-controlled IMAC procedure provides higher specificity than any other one-step IMAC purification procedure and can be adapted to other solid supports, fully automated or manual, for large-scale identification of the vastly under-explored phosphoproteome.
Journal Article

Human lung cancer cell lines exhibit resistance to retinoic acid treatment

TL;DR: Alarms of the RAR-beta system are common in human lung cancer cell lines, and no abnormalities in Rar-alpha gene structure or expression were identified by Southern and Northern blot analysis.