M
Michael I. Lerman
Researcher at National Institutes of Health
Publications - 206
Citations - 22793
Michael I. Lerman is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Tumor suppressor gene & Gene. The author has an hindex of 68, co-authored 206 publications receiving 22082 citations. Previous affiliations of Michael I. Lerman include Science Applications International Corporation & Karolinska Institutet.
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Journal ArticleDOI
Mutations of the VHL tumour suppressor gene in renal carcinoma
James R. Gnarra,K. Tory,Yongkai Weng,Laura S. Schmidt,Ming-Hui Wei,Haiyan I. Li,Farida Latif,S. Liu,F. Chen,Fuh Mei Duh,Irina A. Lubensky,D. R. Duan,C. Florence,Rudy Pozzatti,M. M. Walther,Neil H. Bander,H.B. Grossman,Hiltrud Brauch,S. Pomer,James D. Brooks,William B. Isaacs,Michael I. Lerman,Berton Zbar,W. M. Linehan +23 more
TL;DR: The identification of VHL mutations in a majority of localized and advanced sporadic renal carcinomas and in a second form of hereditary renal carcinoma indicates that the VHL gene plays a critical part in the origin of this malignancy.
Journal ArticleDOI
Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma
James G. Herman,Farida Latif,Yongkai Weng,Michael I. Lerman,Berton Zbar,Song-Yuan Liu,D Samid,D S Duan,James R. Gnarra,W.M. Linehan +9 more
TL;DR: The findings suggest that aberrant methylation of CpG islands may participate in the tumor-suppressor gene inactivations which initiate or cause progression of common human cancers.
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Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas
Laura S. Schmidt,Fuh Mei Duh,F. Chen,Takeshi Kishida,Gladys Glenn,Peter L. Choyke,Stephen W. Scherer,Zhengping Zhuang,Irina A. Lubensky,Michael Dean,Rando Allikmets,Abirami Chidambaram,Ulf S.R. Bergerheim,J. T. Feltis,C. Casadevall,A. Zamarron,M. Bernues,Stéphane Richard,C. J. M. Lips,McClellan M. Walther,Lap-Chee Tsui,Laura Geil,Mary Lou Orcutt,Thomas Stackhouse,J. Lipan,L. Slife,Hiltrud Brauch,Jochen Decker,G. Niehans,M. D. Hughson,Holger Moch,Stefan Storkel,Michael I. Lerman,W.M. Linehan,B. Zbar +34 more
TL;DR: The results suggest that missense mutations located in the MET proto-oncogene lead to constitutive activation of the MET protein and papillary renal carcinomas.
Journal ArticleDOI
Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease
TL;DR: Four clones were isolated from an adult human brain complementary DNA library with an oligonucleotide probe corresponding to the first 20 amino acids of the beta peptide of brain amyloid from Alzheimer's disease, and the 3.5-kilobase messenger RNA was detected in mammalian brains and human thymus.
Journal ArticleDOI
Mutations in a novel gene lead to kidney tumors, lung wall defects, and benign tumors of the hair follicle in patients with the Birt-Hogg-Dubé syndrome.
Michael L. Nickerson,Michelle B. Warren,Jorge R. Toro,Vera Y. Matrosova,Gladys Glenn,Maria L. Turner,Paul H. Duray,Maria J. Merino,Peter L. Choyke,Christian P. Pavlovich,Nirmala Sharma,McClellan M. Walther,David J. Munroe,Robert Hill,Eamonn R. Maher,Cheryl R. Greenberg,Michael I. Lerman,W. Marston Linehan,Berton Zbar,Laura S. Schmidt +19 more
TL;DR: Discovery of disease-causing mutations in BHD, a novel kidney cancer gene associated with renal oncocytoma or chromophobe renal cancer, will contribute to understanding the role of folliculin in pathways common to skin, lung, and kidney development.