J
Jeremy M. Henley
Researcher at University of Bristol
Publications - 270
Citations - 14499
Jeremy M. Henley is an academic researcher from University of Bristol. The author has contributed to research in topics: AMPA receptor & Kainate receptor. The author has an hindex of 60, co-authored 261 publications receiving 13554 citations. Previous affiliations of Jeremy M. Henley include Cornell University & Kyoto University.
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Journal ArticleDOI
Induction of LTP in the hippocampus needs synaptic activation of glutamate metabotropic receptors
Zafar I. Bashir,Zuner A. Bortolotto,Ceri H. Davies,Nicola Berretta,AJ Irving,Andrew Seal,Jeremy M. Henley,David E. Jane,Jeffrey C. Watkins,Graham L. Collingridge +9 more
TL;DR: (RS)-α-methyl-4-carboxyphenylglycine is a specific mGluR antagonist in the hippocampus and this compound is used to examine the nature of the involvement ofmGluRs in LTP, and it is shown that synaptic activation of mGLURs is necessary for the induction of both NMDA receptor-dependent and NMDA receptors-independent forms of LTP inThe hippocampus.
Journal ArticleDOI
Mechanisms, regulation and consequences of protein SUMOylation.
TL;DR: The SUMOylation pathway is briefly described and an overview of the recent findings that are beginning to identify some of the mechanisms that regulate protein SUMoylation are presented.
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NSF Binding to GluR2 Regulates Synaptic Transmission
Atsushi Nishimune,John T.R. Isaac,Elek Molnár,Jacques Noël,S.Russell Nash,Mitsuo Tagaya,Graham L. Collingridge,Shigetada Nakanishi,Jeremy M. Henley,Jeremy M. Henley +9 more
TL;DR: A previously unsuspected direct interaction in the postsynaptic neuron between two major proteins involved in synaptic transmission is demonstrated and a rapid NSF-dependent modulation of AMPA receptor function is suggested.
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Regulation of glutamate release by presynaptic kainate receptors in the hippocampus.
Ramesh Chittajallu,Michel Vignes,Kumlesh K. Dev,Janine M. Barnes,Graham L. Collingridge,Jeremy M. Henley +5 more
TL;DR: Kainate elicits a dose-dependent decrease in L-glutamate release from rat hippocampal synaptosomes and also depresses glutamatergic synaptic transmission, indicating that glutamate release can be modulated directly by kainate autoreceptors.
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Synaptic AMPA receptor composition in development, plasticity and disease.
TL;DR: What is known, uncertain, conjectured and unknown about the roles of the individual subunits of AMPARs, and how they affect AMPAR assembly, trafficking and function under both normal and pathological conditions are discussed.