J
Jérôme Birkenstock
Researcher at University of Mainz
Publications - 11
Citations - 435
Jérôme Birkenstock is an academic researcher from University of Mainz. The author has contributed to research in topics: Experimental autoimmune encephalomyelitis & Multiple sclerosis. The author has an hindex of 7, co-authored 11 publications receiving 302 citations.
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Journal ArticleDOI
Perivascular microglia promote blood vessel disintegration in the ischemic penumbra
Valérie Jolivel,Frank Bicker,Fabien Binamé,Robert Ploen,Stefanie Keller,René Gollan,Betty Jurek,Jérôme Birkenstock,Laura Poisa-Beiro,Julia Bruttger,Verena Opitz,Serge C. Thal,Ari Waisman,Tobias Bäuerle,Michael K. E. Schäfer,Frauke Zipp,Mirko H. H. Schmidt +16 more
TL;DR: Potentially, medication directed at inhibiting microglia activation within the first day after stroke could stabilize blood vessels in the penumbra, increase blood flow, and serve as a valuable treatment for patients suffering from ischemic stroke.
Journal ArticleDOI
In vivo and in vitro effects of multiple sclerosis immunomodulatory therapeutics on glutamatergic excitotoxicity
Dirk Luchtman,René Gollan,Erik Ellwardt,Jérôme Birkenstock,Kerstin Robohm,Volker Siffrin,Frauke Zipp +6 more
TL;DR: In vivo two‐photon imaging in the brain of TN‐XXL transgenic Ca2+ reporter mice suggests that MS drugs may mediate neuroprotection via excitotoxicity modulating effects.
Journal ArticleDOI
Fast direct neuronal signaling via the IL-4 receptor as therapeutic target in neuroinflammation
Christina F. Vogelaar,Shibajee Mandal,Steffen Lerch,Katharina Birkner,Jérôme Birkenstock,Ulrike Bühler,Andrea Schnatz,Cedric S. Raine,Stefan Bittner,Johannes Vogt,Jonathan Kipnis,Jonathan Kipnis,Robert Nitsch,Frauke Zipp +13 more
TL;DR: It is demonstrated that intrathecal IL-4 treatment during the chronic phase of several experimental autoimmune encephalomyelitis models reversed disease progression without affecting inflammation.
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In vivo imaging of lymphocytes in the CNS reveals different behaviour of naïve T cells in health and autoimmunity
Josephine Herz,Magdalena Paterka,Raluca Niesner,Alexander U. Brandt,Volker Siffrin,Tina Leuenberger,Jérôme Birkenstock,Agata Mossakowski,Robert Glumm,Frauke Zipp,Helena Radbruch,Helena Radbruch +11 more
TL;DR: The activation status rather than antigen specificity or regulatory phenotype is the central requirement for CD4+ T cell migration within healthy CNS tissue, and naïve T cells cannot find sufficient migratory signals in healthy, non-inflamed CNS parenchyma.
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Gatekeeper role of brain antigen‐presenting CD11c + cells in neuroinflammation
Magdalena Paterka,Volker Siffrin,Jan Oliver Voss,Johannes Werr,Nicola Hoppmann,René Gollan,Patrick Belikan,Julia Bruttger,Jérôme Birkenstock,Steffen Jung,Enric Esplugues,Nir Yogev,Richard A. Flavell,Tobias Bopp,Frauke Zipp +14 more
TL;DR: The gatekeeper function of CNS professional antigen‐presenting CD11c+ cells is demonstrated, which preferentially interact with Th17 cells, and a fundamental role of CNS CD11C+ cells in the attraction of pathogenic T cells into and their survival within the CNS is demonstrated.