Jerome Boudeau

TL;DR: AIEC strains are associated specifically with ileal mucosa in CD, and the abilities of E. coli strains to invade epithelial cells and to survive and replicate within macrophages were assessed using the gentamicin protection assay.

TL;DR: Findings show that LF82, which colonized the ileal mucosa of a patient with CD, is a true invasive E. coli strain and suggest the existence of a new potentially pathogenic group of E. Escherichia coli strains, which is proposed be designated adherent-invasive E coli.

TL;DR: Findings showed that Escherichia coli strains recovered from Crohn's disease (CD) lesions are able to survive and to replicate within macrophages, and AIEC LF82 replication does not induce any cell death of the infected cells, and LF82-infected J774-A1 cells release high levels of TNF-α.

TL;DR: Findings showed that type 1 pili‐mediated adherence is involved in LF82‐induced perturbation of host cell signalling responsible for membrane elongations, and native shafts are required for type 1 pilus‐mediated induction of membrane elongation.

TL;DR: Pathogenic adherent–invasive Escherichia coli have been isolated from ileal lesions of Crohn's disease and are associated with diarrhoea, vomiting, and encephalopathy.