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Anne-Lise Glasser
Researcher at University of Auvergne
Publications - 19
Citations - 4029
Anne-Lise Glasser is an academic researcher from University of Auvergne. The author has contributed to research in topics: Intestinal mucosa & Innate immune system. The author has an hindex of 15, co-authored 19 publications receiving 3733 citations. Previous affiliations of Anne-Lise Glasser include Institut national de la recherche agronomique.
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Journal ArticleDOI
High prevalence of adherent-invasive Escherichia coli associated with ileal mucosa in Crohn’s disease
Arlette Darfeuille-Michaud,Jerome Boudeau,Philippe Bulois,Christel Neut,Anne-Lise Glasser,Nicolas Barnich,Marie-Agnès Bringer,Alexander Swidsinski,Laurent Beaugerie,Jean-Frederic Colombel +9 more
TL;DR: AIEC strains are associated specifically with ileal mucosa in CD, and the abilities of E. coli strains to invade epithelial cells and to survive and replicate within macrophages were assessed using the gentamicin protection assay.
Journal ArticleDOI
CEACAM6 acts as a receptor for adherent-invasive E. coli , supporting ileal mucosa colonization in Crohn disease
Nicolas Barnich,Frederic A. Carvalho,Anne-Lise Glasser,Claude Darcha,Peter Jantscheff,Matthieu Allez,Harald Peeters,Gilles Bommelaer,Pierre Desreumaux,Jean-Frederic Colombel,Arlette Darfeuille-Michaud +10 more
TL;DR: In vitro studies show that there is increased CEACAM6 expression in cultured intestinal epithelial cells after IFN-gamma or TNF-alpha stimulation and after infection with AIEC bacteria, indicating that AIEC can promote its own colonization in CD patients.
Journal ArticleDOI
Invasive Ability of an Escherichia coli Strain Isolated from the Ileal Mucosa of a Patient with Crohn’s Disease
TL;DR: Findings show that LF82, which colonized the ileal mucosa of a patient with CD, is a true invasive E. coli strain and suggest the existence of a new potentially pathogenic group of E. Escherichia coli strains, which is proposed be designated adherent-invasive E coli.
Journal ArticleDOI
Adherent Invasive Escherichia coli Strains from Patients with Crohn's Disease Survive and Replicate within Macrophages without Inducing Host Cell Death
Anne-Lise Glasser,Jerome Boudeau,Nicolas Barnich,Marie-Helene Perruchot,Jean-Frederic Colombel,Arlette Darfeuille-Michaud +5 more
TL;DR: Findings showed that Escherichia coli strains recovered from Crohn's disease (CD) lesions are able to survive and to replicate within macrophages, and AIEC LF82 replication does not induce any cell death of the infected cells, and LF82-infected J774-A1 cells release high levels of TNF-α.
Journal ArticleDOI
Crohn's disease‐associated adherent‐invasive E. coli are selectively favoured by impaired autophagy to replicate intracellularly
TL;DR: It is shown that functional autophagy limits intrACEllular AIEC replication and that a subpopulation of the intracellular bacteria is located within LC3‐positive autophagosomes, demonstrating a central role for autophagic restraining Adherent‐Invasive E. coli strains associated with ileal CD.