J
Jérôme Durivault
Researcher at University of Nice Sophia Antipolis
Publications - 32
Citations - 1204
Jérôme Durivault is an academic researcher from University of Nice Sophia Antipolis. The author has contributed to research in topics: Vascular endothelial growth factor & Warburg effect. The author has an hindex of 14, co-authored 27 publications receiving 841 citations. Previous affiliations of Jérôme Durivault include French Institute of Health and Medical Research.
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Double genetic disruption of lactate dehydrogenases A and B is required to ablate the
M. Zdralevic,Almut Brand,L. Di Ianni,Katja Dettmer,Jörg Reinders,Katrin Singer,K. Peter,Annette Schnell,Christina Bruss,Sonja-Maria Decking,Gudrun E. Koehl,B. Felipe-Abrio,Jérôme Durivault,Pascale Bayer,Marie Evangelista,Thomas O'Brien,Peter J. Oefner,Kerstin Renner,Jacques Pouysségur,Marina Kreutz +19 more
TL;DR: In this article, the LDHA/B-DKO genes were disrupted in two cancer cell lines (human colon adenocarcinoma and murine melanoma cells) to reveal that the metabolic shift to OXPHOS caused by LDHA and B genetic disruptions is responsible for the tumors' escape and growth.
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Disrupting glucose-6-phosphate isomerase fully suppresses the “Warburg effect” and activates OXPHOS with minimal impact on tumor growth except in hypoxia
Monique Meyenberg Cunha de Padua,Monique Meyenberg Cunha de Padua,Giulia Delodi,Milica Vučetić,Jérôme Durivault,Valérie Vial,Pascale Bayer,Guilhermina Rodrigues Noleto,Nathalie M. Mazure,Maša Ždralević,Jacques Pouysségur +10 more
TL;DR: The results indicate that exclusive use of oxidative metabolism has the capacity to provide metabolic precursors for biomass synthesis and fast growth and clearly indicate that metabolic cancer cell plasticity poses a strong limitation to anticancer strategies.
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Acceleration of clear cell renal cell carcinoma growth in mice following bevacizumab/Avastin treatment: the role of CXCL cytokines.
Renaud Grépin,Mélanie Guyot,Marie A. Jacquin,Jérôme Durivault,Chamorey E,Sudaka A,Cindy Serdjebi,Lacarelle B,Jean-Yves Scoazec,Negrier S,Simonnet H,Gilles Pagès +11 more
TL;DR: It is reported that BVZ accelerates the growth of RCC in nude mice with in vivo selection of tumor cells with an increased growth capacity, and doctors recommend proceeding with caution in the use of anti-VEGF therapy alone for treatment of R CC.
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Fas palmitoylation by the palmitoyl acyltransferase DHHC7 regulates Fas stability
Aurélie Rossin,Jérôme Durivault,Chakhtoura-Feghali T,Nadia Lounnas,Laurent Gagnoux-Palacios,Anne-Odile Hueber +5 more
TL;DR: The modification of Fas by palmitoylation is described as a novel mechanism for the regulation of Fas expression through its ability to circumvent its degradation by lysosomal proteolysis.
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Genetic disruption of the pHi-regulating proteins Na+/H+ exchanger 1 (SLC9A1) and carbonic anhydrase 9 severely reduces growth of colon cancer cells.
TL;DR: Investigating the role of CA9 via complete genomic knockout and compared its impact on tumor cell physiology with the essential pHi regulator Na+/H+ exchanger 1 (NHE1) strengthen the pursuit of targeting tumor cell pH regulation as an effective anti-cancer strategy.