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Yann Cormerais
Researcher at Harvard University
Publications - 19
Citations - 882
Yann Cormerais is an academic researcher from Harvard University. The author has contributed to research in topics: Cancer cell & mTORC1. The author has an hindex of 12, co-authored 19 publications receiving 632 citations.
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Journal ArticleDOI
Genetic Disruption of the Multifunctional CD98/LAT1 Complex Demonstrates the Key Role of Essential Amino Acid Transport in the Control of mTORC1 and Tumor Growth
Yann Cormerais,Sandy Giuliano,Renaud Lefloch,Benoît Front,Jérôme Durivault,Eric Tambutté,Pierre-André Massard,Laura R. de la Ballina,Hitoshi Endou,Michael F. Wempe,Manuel Palacín,Scott K. Parks,Jacques Pouysségur +12 more
TL;DR: It is established that LAT1 transport activity is the key growth-limiting step of the heterodimer and advocate the pharmacology development of LAT1 transporter inhibitors as a very promising anticancer target.
Journal ArticleDOI
Genetic ablation of the cystine transporter xCT in PDAC cells inhibits mTORC1, growth, survival and tumor formation via nutrient and oxidative stresses
Boutaina Daher,Scott K. Parks,Jérôme Durivault,Yann Cormerais,Hanane Baidarjad,Eric Tambutté,Jacques Pouysségur,Milica Vučetić +7 more
TL;DR: In vitro pharmacological inhibition of xCT by low concentrations of erastin phenocopied xCT-KO and potentiated the cytotoxic effects of both gemcitabine and cisplatin in PDAC cell lines strongly support that inhibition ofxCT, by its dual induction of nutritional and oxidative cellular stresses, has great potential as an anticancer strategy.
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The glutamine transporter ASCT2 (SLC1A5) promotes tumor growth independently of the amino acid transporter LAT1 (SLC7A5)
Yann Cormerais,Pierre André Massard,Milica Vučetić,Sandy Giuliano,Eric Tambutté,Jérôme Durivault,Valérie Vial,Hitoshi Endou,Michael F. Wempe,Scott K. Parks,Jacques Pouysségur +10 more
TL;DR: ASCT2KO reduces tumor growth by limiting AA import, but that this effect is independent of LAT1 activity, which indicates that the proposed functional coupling model of ASCT2 and LAT1 is not universal across different cancer types.
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Hypoxia and cellular metabolism in tumour pathophysiology.
TL;DR: Evidence is provided for a number of hypoxia‐induced proteins that promote cellular anabolism and regulation of metabolic acid–base levels in tumour cells including amino‐acid transporters (LAT1), monocarboxylatetransporters, and acid– base regulating carbonic anhydrases (CAs) and bicarbonate transportters (NBCs).
Journal ArticleDOI
Resistance to sunitinib in renal clear cell carcinoma results from sequestration in lysosomes and inhibition of the autophagic flux
Sandy Giuliano,Yann Cormerais,Maeva Dufies,Renaud Grépin,Pascal Colosetti,Amine Belaid,Julien Parola,Anthony Martin,Sandra Lacas-Gervais,Nathalie M. Mazure,Rachid Benhida,Patrick Auberger,Baharia Mograbi,Gilles Pagès +13 more
TL;DR: A new therapeutic approach is proposed combining sunitinib with molecules that prevent lysosomal accumulation or inhibit the proteasome to maintain a cellular homeostasis of mRCC.