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Anne-Odile Hueber
Researcher at French Institute of Health and Medical Research
Publications - 72
Citations - 4077
Anne-Odile Hueber is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Fas receptor & Fas ligand. The author has an hindex of 31, co-authored 71 publications receiving 3849 citations. Previous affiliations of Anne-Odile Hueber include Lincoln's Inn & University of Nice Sophia Antipolis.
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Journal ArticleDOI
The CD95 receptor: apoptosis revisited.
Marcus E. Peter,Ralph C. Budd,Julie Desbarats,Stephen M. Hedrick,Anne-Odile Hueber,M. Karen Newell,Laurie B. Owen,Richard M. Pope,Juerg Tschopp,Harald Wajant,David Wallach,Robert H. Wiltrout,Martin Zörnig,David H. Lynch +13 more
TL;DR: Evidence suggests that CD95 mediates not only apoptosis but also diverse nonapoptotic functions depending on the tissue and the conditions.
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Requirement for the CD95 Receptor-Ligand Pathway in c-Myc-Induced Apoptosis
Anne-Odile Hueber,Martin Zörnig,Martin Zörnig,Debbie Lyon,Debbie Lyon,Takashi Suda,Takashi Suda,Shigekazu Nagata,Gerard I. Evan,Gerard I. Evan +9 more
TL;DR: Findings link two apoptotic pathways previously thought to be independent and establish the dependency of Myc on CD95 signaling for its killing activity and suppress c-myc-induced apoptosis by also acting downstream of CD95.
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c-Myc-induced sensitization to apoptosis is mediated through cytochrome c release
TL;DR: It is concluded that c-Myc promotes apoptosis by causing the release of cytochrome c, but the ability of cy tochrome c to activate apoptosis is critically dependent upon other signals.
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Apoptosis regulators and their role in tumorigenesis.
TL;DR: The evidence that impaired PCD is a prerequisite for tumorigenesis, as indicated by the fact that more and more neoplastic mutations appear to act by interfering with PCD, is summarized.
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An essential role for membrane rafts in the initiation of Fas/CD95-triggered cell death in mouse thymocytes.
TL;DR: It is reported here that a considerable fraction of Fas is constitutively partitioned into sphingolipid‐ and cholesterol‐rich membrane rafts in mouse thymocytes as well as the L12.10‐Fas T cells, and Fas ligation promotes a rapid and specific recruitment of FADD and caspase‐8 to the rafts.