J
Jerripothula K. Lakshmi
Researcher at Indian Institute of Chemical Technology
Publications - 18
Citations - 113
Jerripothula K. Lakshmi is an academic researcher from Indian Institute of Chemical Technology. The author has contributed to research in topics: Prins reaction & Michael reaction. The author has an hindex of 5, co-authored 17 publications receiving 80 citations. Previous affiliations of Jerripothula K. Lakshmi include Osmania University.
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Journal ArticleDOI
Peptidomimetic organocatalysts: efficient Michael addition of ketones onto nitroolefins with very low catalyst loading
Srivari Chandrasekhar,Chintakunta Praveen Kumar,Togapur Pavan Kumar,Kothapalli Haribabu,Bharatam Jagadeesh,Jerripothula K. Lakshmi,Prathama S. Mainkar +6 more
TL;DR: In this article, two peptidomimetic triazole-based organocatalysts were synthesized for the asymmetric conjugate addition of cyclohexanone to nitroolefins.
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Synthetic Strategy toward the Pentacyclic Core of Melodinus Alkaloids.
Navya Goli,Shivakrishna Kallepu,Prathama S. Mainkar,Jerripothula K. Lakshmi,Rambabu Chegondi,Srivari Chandrasekhar +5 more
TL;DR: The three-component Povarov reaction is efficiently utilized for construction of the pentacyclic framework of complex Melodinus alkaloids, which is amenable to expansion to other complex natural products.
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Synthesis, structural studies, and cytotoxic evaluation of novel ursolic acid hybrids with capabilities to arrest breast cancer cells in mitosis.
Banita Pattnaik,Jerripothula K. Lakshmi,Rachineni Kavitha,Bharatam Jagadeesh,Debanjan Bhattacharjee,Nishant Jain,Uppuluri Venkata Mallavadhani +6 more
TL;DR: Compound 17 is the most potent one with GI50 value of 1.4 ± 0.1 μM and showed 2.9 times more activity than the standard doxorubicin against MDA-MB-231, resulting in a change in cell phenotype.
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Synthesis of imidazo-thiadiazole linked indolinone conjugates and evaluated their microtubule network disrupting and apoptosis inducing ability.
M. P. Narasimha Rao,Burri Nagaraju,Jeshma Kovvuri,Sowjanya Polepalli,Sateesh Alavala,M.V.P.S. Vishnuvardhan,P. Swapna,Vijaykumar D. Nimbarte,Jerripothula K. Lakshmi,Nishant Jain,Ahmed Kamal +10 more
TL;DR: Docking studies revealed that these compounds (7, 14 and 15) bind with αAsn101, αThr179, αSer178, βCys241, βLys254 andβLys352 in the colchicine-binding site of the tubulin.
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A divergent, short, and stereoselective approach to pyrrolidine iminosugars: synthesis of 1,4-dideoxy-1,4-imino-derivatives of d-allitol, d-ribitol, ethyl-erythritol, and (−)-2,3-trans-3-4-cis-dihydroxyproline
Sahadev S. Chirke,Sahadev S. Chirke,A. Rajender,Jerripothula K. Lakshmi,Batchu Venkateswara Rao,Batchu Venkateswara Rao +5 more
TL;DR: A highly stereoselective addition of Grignard reagent on lactamine for the synthesis of 1, 4-dideoxy-1,4-imino-derivatives of d-allitol, d-ribitol, ethyl-erythritol, and (−)-2,3-trans-3-4-cis-dihydroxyproline has been described from commercially available d- ribose as a starting material.