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Jerry J. Buccafusco

Researcher at United States Department of Veterans Affairs

Publications -  83
Citations -  3429

Jerry J. Buccafusco is an academic researcher from United States Department of Veterans Affairs. The author has contributed to research in topics: Cholinergic & Muscarinic acetylcholine receptor. The author has an hindex of 33, co-authored 83 publications receiving 3321 citations. Previous affiliations of Jerry J. Buccafusco include Georgia Regents University.

Papers
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Multi-functional drugs for various CNS targets in the treatment of neurodegenerative disorders

Moussa B.H. Youdim, +2 more
- 01 Jan 2005 - 
TL;DR: Bi- or multi-functional compounds that combine two or more of the following properties might provide greater symptomatic efficacy, and better utility as potential neuroprotective disease-modifying drugs.
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m1-m5 muscarinic receptor distribution in rat CNS by RT-PCR and HPLC.

Jian Wei, +3 more
- 23 Nov 2002 - 
TL;DR: The combination of RT‐PCR and HPLC provides a rapid and sensitive method for quantifying the expression of mRNA coding for all five muscarinic receptor subtypes derived from the CNS.
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Long-lasting cognitive improvement with nicotinic receptor agonists: mechanisms of pharmacokinetic–pharmacodynamic discordance

Jerry J. Buccafusco, +4 more
- 01 Jul 2005 - 
TL;DR: Some of the cellular effects of nAChR agonists overlap with the known cellular mechanisms of LTP, including long-lasting increases in intracellular concentrations of Ca2+, activation of second-messenger systems and transcription factors, elevated levels of gene products and enhanced neurotransmitter release.
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Relationship between the increased cell surface alpha7 nicotinic receptor expression and neuroprotection induced by several nicotinic receptor agonists.

Ramamohana R. Jonnala, +2 more
- 15 Nov 2001 - 
TL;DR: The induced upregulation of the α7 subtype of nicotinic receptors during chronic exposure to nicotine may be responsible for the drug's neuroprotective action.
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Autoimmunity in Alzheimer’s disease: increased levels of circulating IgGs binding Aβ and RAGE peptides

Shyamala Mruthinti, +8 more
- 01 Sep 2004 - 
TL;DR: Findings confirm the presence of circulating IgGs specifically directed at proteins implicated in immunological processes linked to AD and suggest the possibility that the antibodies are being produced in response to a common mechanism or protein complex linked to the disease.