J
Jesse M. Damsker
Researcher at National Institutes of Health
Publications - 41
Citations - 1719
Jesse M. Damsker is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Duchenne muscular dystrophy & Inflammation. The author has an hindex of 20, co-authored 39 publications receiving 1447 citations. Previous affiliations of Jesse M. Damsker include George Washington University & Washington University in St. Louis.
Papers
More filters
Journal ArticleDOI
Deficient inflammatory response to UV radiation in neonatal mice
Agnieszka Wolnicka-Glubisz,Jesse M. Damsker,Stephanie L. Constant,Stephanie Corn,Edward C. De Fabo,Frances P. Noonan +5 more
TL;DR: It is proposed this neonatal deficiency in the inflammatory response is a significant, previously unrecognized factor in neonatal immune tolerance and may contribute to neonatal susceptibility to cancer, including melanoma and other UV‐induced cancers.
Journal ArticleDOI
Amine-reactive OVA multimers for auto-vaccination against cytokines and other mediators: perspectives illustrated for GCP-2 in L. major infection.
Catherine Uyttenhove,Reece Gerrad Marillier,Reece Gerrad Marillier,Fabienne Tacchini-Cottier,Mélanie Charmoy,Rachel R. Caspi,Jesse M. Damsker,Stanislas Goriely,Dan Su,Jo Van Damme,Sofie Struyf,Ghislain Opdenakker,Jacques Van Snick,Jacques Van Snick +13 more
TL;DR: Using a mAb against GCP‐2, obtained by the method described here, the first demonstration of the major role played by this chemokine in rapid neutrophil mobilization after Leishmania major infection is provided.
Journal ArticleDOI
Δ-9,11 Modification of Glucocorticoids Dissociates Nuclear Factor-κB Inhibitory Efficacy from Glucocorticoid Response Element-Associated Side Effects
Andreas R. Baudy,Erica K.M. Reeves,Jesse M. Damsker,Christopher R. Heier,Lindsay M. Garvin,Blythe C. Dillingham,John M. McCall,Sree Rayavarapu,Zuyi Wang,Jack Vandermeulen,Arpana Sali,Vanessa E. Jahnke,Stephanie Duguez,Debra C. DuBois,Mary C. Rose,Kanneboyina Nagaraju,Eric P. Hoffman +16 more
TL;DR: The data demonstrate that a Δ-9,11 analog dissociates the GR-mediated transcriptional activities from anti-inflammatory activities, and may hold promise as a source of safer therapeutic agents for chronic inflammatory disorders.
Journal ArticleDOI
Blocking cyclophilins in the chronic phase of asthma reduces the persistence of leukocytes and disease reactivation.
Erik J. Stemmy,Molly A. Balsley,Rosalyn A. Jurjus,Jesse M. Damsker,Michael Bukrinsky,Stephanie L. Constant +5 more
TL;DR: Using a new murine model of chronic allergic asthma, elevated concentrations of extracellular cyclophilin A, but not classic chemokines, were indeed detected during the chronic phase of asthma, and blocking the activity of cyclophiles during this phase reduced the number of persisting leukocytes by up to 80%.
Journal ArticleDOI
Muscle miRNAome shows suppression of chronic inflammatory miRNAs with both prednisone and vamorolone.
Alyson A. Fiorillo,Alyson A. Fiorillo,Christopher B. Tully,Jesse M. Damsker,Kanneboyina Nagaraju,Eric P. Hoffman,Christopher R. Heier,Christopher R. Heier +7 more
TL;DR: Vamorolone (VBP15) is developed, a first-in-class dissociative glucocorticoid receptor (GR) ligand that shows the anti-inflammatory efficacy of corticosteroids without key steroid side effects in animal models, and bioinformatic analyses showed all of these miRNAs are directly regulated by, or in turn activate, the inflammatory transcription factor NF-κB.