S
Stanislas Goriely
Researcher at Université libre de Bruxelles
Publications - 101
Citations - 5248
Stanislas Goriely is an academic researcher from Université libre de Bruxelles. The author has contributed to research in topics: Immune system & Interleukin 12. The author has an hindex of 37, co-authored 93 publications receiving 4476 citations. Previous affiliations of Stanislas Goriely include Université catholique de Louvain & Technische Universität München.
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Journal ArticleDOI
Innate Immune Function by Toll-like Receptors: Distinct Responses in Newborns and the Elderly
TL;DR: Development patterns of distinct Toll-like-receptor-mediated immune responses come to light when one contrasts innate immune development at the beginning of life with that toward the end of life, and these developmental patterns of innate cytokine responses correlate with clinical patterns of susceptibility to disease.
Journal ArticleDOI
Deficient IL-12(p35) Gene Expression by Dendritic Cells Derived from Neonatal Monocytes
Stanislas Goriely,Benoit Vincart,Patrick Stordeur,Johan Vekemans,Fabienne Willems,Michel Goldman,Dominique De Wit +6 more
TL;DR: It is concluded that neonatal DC are characterized by a severe defect in IL-12(p35) gene expression which is responsible for an impaired ability to elicit IFN-γ production by T cells.
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Cytokine mRNA quantification by real-time PCR.
Patrick Stordeur,Lionel F. Poulin,Ligia Craciun,Ling Zhou,Liliane Schandené,Aurore de Lavareille,Stanislas Goriely,Michel Goldman +7 more
TL;DR: The reproducibility of the method using hydrolysis probes compares favourably with that obtained with hybridisation probes and the method was used successfully to demonstrate that IFN-alpha induces IL-10 mRNA accumulation in human monocytes.
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CXCL13-producing TFH cells link immune suppression and adaptive memory in human breast cancer
Chunyan Gu-Trantien,Edoardo Migliori,Laurence Buisseret,Alexandre de Wind,Sylvain Brohée,Soizic Garaud,Grégory Noël,Vu Luan Dang Chi,Jean Nicolas Lodewyckx,Céline Naveaux,Hugues Duvillier,Stanislas Goriely,Denis Larsimont,Karen Willard-Gallo +13 more
TL;DR: The data suggest that human TFHX13 cell differentiation may be a key factor in converting Treg-mediated immune suppression to de novo activation of adaptive antitumor humoral responses in the chronic inflammatory breast cancer microenvironment.
Journal ArticleDOI
A defect in nucleosome remodeling prevents IL-12(p35) gene transcription in neonatal dendritic cells.
Stanislas Goriely,Carine Van Lint,Réza Dadkhah,Myriam Libin,Dominique De Wit,Dominique Demonte,Fabienne Willems,Michel Goldman +7 more
TL;DR: It is concluded that IL-12(p35) transcriptional repression in neonatal DCs takes place at the chromatin level.