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Blythe C. Dillingham
Researcher at Children's National Medical Center
Publications - 11
Citations - 673
Blythe C. Dillingham is an academic researcher from Children's National Medical Center. The author has contributed to research in topics: Prednisolone & Inflammation. The author has an hindex of 9, co-authored 10 publications receiving 566 citations. Previous affiliations of Blythe C. Dillingham include Scripps Research Institute & University of California, San Diego.
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Journal ArticleDOI
Direct reactivation of a coherent neocortical memory of context.
Kiriana K. Cowansage,Tristan Shuman,Blythe C. Dillingham,Allene Chang,Peyman Golshani,Mark Mayford +5 more
TL;DR: A c-fos-based genetic tagging system is used to selectively express the channelrhodopsin variant, ChEF, and optogenetically reactivate a specific neural ensemble in retrosplenial cortex engaged by context fear conditioning, suggesting that higher-order cortical framework can independently subserve learned behavior, even shortly after learning.
Journal ArticleDOI
VBP15, a novel anti-inflammatory and membrane-stabilizer, improves muscular dystrophy without side effects
Christopher R. Heier,Jesse M. Damsker,Qing Yu,Blythe C. Dillingham,Tony Huynh,Jack H. Van der Meulen,Arpana Sali,Brittany K. Miller,Aditi Phadke,Luana Scheffer,James L Quinn,Kathleen Tatem,Sarah Jordan,Sherry Dadgar,Olga Rodriguez,Chris Albanese,Michael E. Calhoun,Heather Gordish-Dressman,Jyoti K. Jaiswal,Edward M. Connor,John M. McCall,Eric P. Hoffman,Erica K.M. Reeves,Kanneboyina Nagaraju +23 more
TL;DR: Successful improvement of dystrophy independent of hormonal, growth, or immunosuppressive effects is demonstrated, indicating VBP15 merits clinical investigation for DMD and would benefit other chronic inflammatory diseases.
Journal ArticleDOI
Expanding Reactivity in DNA-Encoded Library Synthesis via Reversible Binding of DNA to an Inert Quaternary Ammonium Support
Dillon T. Flood,Shota Asai,Xuejing Zhang,Xuejing Zhang,Jie Wang,Leonard Yoon,Zoë C Adams,Blythe C. Dillingham,Brittany Sanchez,Julien C. Vantourout,Mark Edward Flanagan,David W. Piotrowski,Paul G. Richardson,Samantha A. Green,Ryan A. Shenvi,Jason S. Chen,Phil S. Baran,Philip E. Dawson +17 more
TL;DR: The RASS approach enabled the rapid development of C(sp2)-C(sp3) decarboxylative cross-couplings with broad substrate scope, an electrochemical amination (the first electrochemical synthetic transformation performed in a DEL context), and improved reductive amination conditions.
Journal ArticleDOI
Δ-9,11 Modification of Glucocorticoids Dissociates Nuclear Factor-κB Inhibitory Efficacy from Glucocorticoid Response Element-Associated Side Effects
Andreas R. Baudy,Erica K.M. Reeves,Jesse M. Damsker,Christopher R. Heier,Lindsay M. Garvin,Blythe C. Dillingham,John M. McCall,Sree Rayavarapu,Zuyi Wang,Jack Vandermeulen,Arpana Sali,Vanessa E. Jahnke,Stephanie Duguez,Debra C. DuBois,Mary C. Rose,Kanneboyina Nagaraju,Eric P. Hoffman +16 more
TL;DR: The data demonstrate that a Δ-9,11 analog dissociates the GR-mediated transcriptional activities from anti-inflammatory activities, and may hold promise as a source of safer therapeutic agents for chronic inflammatory disorders.
Journal ArticleDOI
VBP15, a Glucocorticoid Analogue, Is Effective at Reducing Allergic Lung Inflammation in Mice
Jesse M. Damsker,Blythe C. Dillingham,Mary C. Rose,Mary C. Rose,Molly A. Balsley,Christopher R. Heier,Alan M. Watson,Erik J. Stemmy,Rosalyn A. Jurjus,Tony Huynh,Tony Huynh,Kathleen Tatem,Kitipong Uaesoontrachoon,Dana M. Berry,Angela S. Benton,Robert J. Freishtat,Robert J. Freishtat,Eric P. Hoffman,Eric P. Hoffman,John M. McCall,Heather Gordish-Dressman,Heather Gordish-Dressman,Stephanie L. Constant,Erica K.M. Reeves,Kanneboyina Nagaraju,Kanneboyina Nagaraju +25 more
TL;DR: VBP15 is as effective as the traditional glucocorticoid, prednisolone, at reducing three major hallmarks of lung inflammation—NFκB activity, leukocyte degranulation, and pro-inflammatory cytokine release from human bronchial epithelial cells obtained from patients with asthma.