J
Jessica A. Thompson
Researcher at Instituto Gulbenkian de Ciência
Publications - 18
Citations - 2155
Jessica A. Thompson is an academic researcher from Instituto Gulbenkian de Ciência. The author has contributed to research in topics: Gut flora & Quorum sensing. The author has an hindex of 10, co-authored 17 publications receiving 1739 citations. Previous affiliations of Jessica A. Thompson include Imperial College London & Universidade Nova de Lisboa.
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Journal ArticleDOI
The Multiple Signaling Systems Regulating Virulence in Pseudomonas aeruginosa
Pol Nadal Jimenez,Pol Nadal Jimenez,Gudrun Koch,Gudrun Koch,Jessica A. Thompson,Karina B. Xavier,Robbert H. Cool,Wim J. Quax +7 more
TL;DR: This overview clearly illustrates that bacterial communication is far more complex than initially thought and delivers a clear distinction between signals that are quorum sensing dependent and those relying on alternative factors for their production.
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AI‐2‐mediated signalling in bacteria
Catarina S. Pereira,Catarina S. Pereira,Jessica A. Thompson,Jessica A. Thompson,Karina B. Xavier,Karina B. Xavier +5 more
TL;DR: A comprehensive review of the discovery and early characterization of AI-2, current developments in signal detection, transduction and regulation, and the major studies investigating the phenotypes regulated by this molecule is presented.
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Manipulation of the quorum sensing signal AI-2 affects the antibiotic-treated gut microbiota.
Jessica A. Thompson,Rita Almeida Oliveira,Ana Djukovic,Carles Ubeda,Karina B. Xavier,Karina B. Xavier +5 more
TL;DR: This work engineered the enteric bacterium, Escherichia coli, to manipulate the levels of the interspecies quorum sensing signal, autoinducer-2 (AI-2), in the mouse intestine and investigated the effect upon antibiotic-induced gut microbiota dysbiosis.
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Dynamics of intracellular bacterial replication at the single cell level
TL;DR: This work reports the development of a reporter system based on fluorescence dilution that enables direct quantification of the replication dynamics of Salmonella enterica serovar Typhimurium in murine macrophages at both the population and single-cell level and finds that, upon entry into macrophage, many bacteria do not replicate, but appear to enter a dormant-like state.
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SpvC is a Salmonella effector with phosphothreonine lyase activity on host mitogen-activated protein kinases
Piotr Mazurkiewicz,Jerry Thomas,Jessica A. Thompson,Mei Liu,Laurence Arbibe,Philippe J. Sansonetti,David W. Holden +6 more
TL;DR: A strain carrying a deletion in spvC is constructed and it is shown that the strain is attenuated for systemic virulence in mice and has phosphothreonine lyase activity on full‐length phospho‐Erk (pErk) and a synthetic 13‐amino‐acidospho‐peptide containing the TXY motif.