Jessica D. Wiley

TL;DR: It is demonstrated that FISC is the obligatory partner of Met for binding to JH-response elements (JHREs) and the optimal DNA sequence recognized by Met and FISC contained a core consensus sequence GCACGTG.

TL;DR: A structure–activity relationship study suggested that the presence of an α,β-unsaturated carbonyl moiety is not essential for potent antimalarial activity.

TL;DR: This study showed that production of IPP for isoprenoid biosynthesis is the essential metabolic function of the apicoplast during gametocytogenesis, by obtaining normal gametocytes lacking the apICoplast when supplemented with IPP.

TL;DR: Ten new neolignans including the 6'-oxo-8.1'-lignan sibyllenone from the stems or bark of the Madagascan plant Ocotea cymosa are isolated on the basis of spectroscopic evidence, including 1D and 2D NMR spectra, electronic circular dichroism, and mass spectrometry, and the biological activities of the new and known compounds.

TL;DR: Three new lignans isolated from Cleistanthus boivinianus showed potent antiproliferative activities against the A2780 ovarian cancer cell line, and compounds 1, 4, and 5 showed potent antimicrobial activity against the HCT-116 human colon carcinoma cell line.