M
Marcelo Jacobs-Lorena
Researcher at Johns Hopkins University
Publications - 171
Citations - 9662
Marcelo Jacobs-Lorena is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Plasmodium berghei & Anopheles gambiae. The author has an hindex of 58, co-authored 162 publications receiving 8795 citations. Previous affiliations of Marcelo Jacobs-Lorena include Imperial College London & Massachusetts Institute of Technology.
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Journal ArticleDOI
Transgenic anopheline mosquitoes impaired in transmission of a malaria parasite
TL;DR: The use of genetic manipulation tools to generate transgenic mosquitoes that express antiparasitic genes in their midgut epithelium are reported, thus rendering them inefficient vectors for the disease.
Journal ArticleDOI
Malaria Control with Genetically Manipulated Insect Vectors
Luke Alphey,C. Ben Beard,Peter F. Billingsley,Maureen Coetzee,Andrea Crisanti,C. F. Curtis,Paul Eggleston,Charles Godfray,Janet Hemingway,Marcelo Jacobs-Lorena,Anthony A. James,Fotis C. Kafatos,Louis G. Mukwaya,Michael Paton,Jeffrey R. Powell,William Schneider,Thomas W. Scott,Barbara Sina,Robert E. Sinden,Steven P. Sinkins,Andrew Spielman,Yeya T. Touré,Frank H. Collins +22 more
TL;DR: At a recent workshop, experts discussed the benefits, risks, and research priorities associated with using genetically manipulated insects in the control of vector-borne diseases.
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Initiation of Haemoglobin Synthesis by Methionyl-tRNA
TL;DR: The synthesis of haemoglobin in a cell free system containing yeast tRNA is initiated by a specific methionine tRNA, which responds to internal codons in the messenger.
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Development of Transgenic Fungi That Kill Human Malaria Parasites in Mosquitoes
Weiguo Fang,Joel Vega-Rodríguez,Anil K. Ghosh,Marcelo Jacobs-Lorena,Angray S. Kang,Raymond J. St. Leger +5 more
TL;DR: Rec recombinant strains expressing molecules that target sporozoites as they travel through the hemolymph to the salivary glands reduced sporozoite counts by 98%, suggesting that Metarhizium-mediated inhibition of Plasmodium development could be a powerful weapon for combating malaria.
Journal ArticleDOI
Fighting malaria with engineered symbiotic bacteria from vector mosquitoes
Sibao Wang,Anil K. Ghosh,Nicholas J. Bongio,Kevin A. Stebbings,Kevin A. Stebbings,David J. Lampe,Marcelo Jacobs-Lorena +6 more
TL;DR: The use of an engineered symbiotic bacterium to interfere with the development of P. falciparum in the mosquito is demonstrated, providing the foundation for the use of genetically modified symbiotic bacteria as a powerful tool to combat malaria.