J
Jessica E. Thorpe
Researcher at University of Oklahoma
Publications - 32
Citations - 2744
Jessica E. Thorpe is an academic researcher from University of Oklahoma. The author has contributed to research in topics: Endothelial dysfunction & Diabetes mellitus. The author has an hindex of 19, co-authored 32 publications receiving 2439 citations. Previous affiliations of Jessica E. Thorpe include University of Oklahoma Health Sciences Center.
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Journal ArticleDOI
Oscillating glucose is more deleterious to endothelial function and oxidative stress than mean glucose in normal and type 2 diabetic patients
Antonio Ceriello,Katherine Esposito,Ludovica Piconi,Michael A. Ihnat,Jessica E. Thorpe,Roberto Testa,Massimo Boemi,Dario Giugliano +7 more
TL;DR: It is suggested that oscillating glucose can have more deleterious effects than constant high glucose on endothelial function and oxidative stress, two key players in favoring cardiovascular complications in diabetes.
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The "metabolic memory": is more than just tight glucose control necessary to prevent diabetic complications?
TL;DR: The emergence of this metabolic memory suggests the need for early aggressive treatment aiming to "normalize" metabolic control together perhaps with the addition of agents which reduce cellular reactive species and glycation in order to minimize long-term diabetic complications.
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Reactive oxygen species mediate a cellular ‘memory’ of high glucose stress signalling
Michael A. Ihnat,Jessica E. Thorpe,Chandrashekhar D. Kamat,Csaba Szabó,Dixy E. Green,Linda A. Warnke,Z. Lacza,A. Cselenyák,K. Ross,S. Shakir,Ludovica Piconi,R. C. Kaltreider,Antonio Ceriello +12 more
TL;DR: These results provide proof-of-principle of a ROS-mediated cellular persistence of vascular stress after glucose normalisation, and were obtained in the retina of diabetic rats with α-lipoic acid added to the last week of normalised glucose.
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Hypothesis: the 'metabolic memory', the new challenge of diabetes.
TL;DR: The emergence of this ‘metabolic memory’ suggests the need for very early aggressive treatment aiming to ‘normalize’ glycaemic control and the addition of agents which reduce cellular reactive species and glycation in order to minimize long‐term diabetic complications.
Journal ArticleDOI
Chronic exposure to arsenic in the drinking water alters the expression of immune response genes in mouse lung.
Courtney D. Kozul,Thomas H. Hampton,Jennifer C. Davey,Julie A. Gosse,Athena P. Nomikos,Phillip L. Eisenhauer,Daniel J. Weiss,Jessica E. Thorpe,Michael A. Ihnat,Joshua W. Hamilton +9 more
TL;DR: Findings indicate that chronic low-dose As exposure at the current U.S. drinking-water standard can elicit effects on the regulation of innate immunity, which may contribute to altered disease risk, particularly in lung.