Jessica Saunders

TL;DR: The data suggest that the formation of lipophilic ionic liquids provides a means of increasing dissolved-drug loading in lipid based formulations and thereby promoting the exposure of poorly water-soluble drugs after oral administration.

TL;DR: This is the first data set to describe in vitro properties for 45 legacy and development anti-malarial drugs and will be a valuable tool for malaria researchers aiming to develop PBPK models for the prediction of human PK properties and/or drug–drug interactions.

TL;DR: A systematic study of nitroheterocyclic drug efficacy using highly sensitive bioluminescence imaging of murine infections finds both drugs are more effective at curing chronic infections, judged by treatment duration and therapeutic dose.

TL;DR: Pharmacokinetic data suggested that biological efficacy most likely resides with the sulfone metabolite (or subsequent reactive metabolites formed following reduction of the nitro group) following administration of either the sulfoxide or the sulf one and that prolonged plasma exposure over the 24-h dosing window is required to achieve high cure rates.

TL;DR: The findings show that the prodrug strategy represents a viable approach to overcome the physicochemical limitations of ELQ-300 to deliver the active drug to the bloodstream at concentrations sufficient for safety and toxicology studies, as well as achieving single-dose cures of patent malaria infections in mice.