K
Kasiram Katneni
Researcher at Monash University
Publications - 21
Citations - 949
Kasiram Katneni is an academic researcher from Monash University. The author has contributed to research in topics: Plasmodium falciparum & Dihydroorotate dehydrogenase. The author has an hindex of 10, co-authored 20 publications receiving 754 citations.
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Journal ArticleDOI
Structure-Guided Lead Optimization of Triazolopyrimidine-Ring Substituents Identifies Potent Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors with Clinical Candidate Potential
Jose M. Coteron,Maria L. Marco,Jorge Esquivias,Xiaoyi Deng,Karen L. White,John H. White,Maria Koltun,Farah El Mazouni,Sreekanth Kokkonda,Kasiram Katneni,Ravi K. Bhamidipati,David M. Shackleford,Iñigo Angulo-Barturen,Santiago Ferrer,María Belén Jiménez-Díaz,Francisco-Javier Gamo,Elizabeth J. Goldsmith,William N. Charman,Ian Bathurst,David M. Floyd,David Matthews,Jeremy N. Burrows,Pradipsinh K. Rathod,Susan A. Charman,Margaret A. Phillips +24 more
TL;DR: These studies have identified the first candidate in the triazolopyrimidine series to meet previously established progression criteria for efficacy and ADME properties, justifying further development of this compound toward clinical candidate status.
Journal ArticleDOI
Endochin-like quinolones are highly efficacious against acute and latent experimental toxoplasmosis
J. Stone Doggett,Aaron Nilsen,Isaac P. Forquer,Keith W. Wegmann,Lorraine Jones-Brando,Robert H. Yolken,Claudia Bordón,Susan A. Charman,Kasiram Katneni,Tracey L. Schultz,Jeremy N. Burrows,David J. Hinrichs,Brigitte Meunier,Vern B. Carruthers,Michael K. Riscoe +14 more
TL;DR: ELQ-271 and ELQ-316 are orally bioavailable drugs that are effective against acute and latent toxoplasmosis, likely acting as inhibitors of the Qi site of the T. gondii cytochrome bc1 complex.
Journal ArticleDOI
Discovery, Synthesis, and Optimization of Antimalarial 4(1H)-Quinolone-3-Diarylethers
Aaron Nilsen,Galen P. Miley,Isaac P. Forquer,Michael W. Mather,Kasiram Katneni,Yuexin Li,Sovitj Pou,April M. Pershing,Allison M. Stickles,Eileen Ryan,Jane X. Kelly,J. Stone Doggett,Karen L. White,David J. Hinrichs,Rolf W. Winter,Susan A. Charman,Lev N. Zakharov,Ian Bathurst,Jeremy N. Burrows,Akhil B. Vaidya,Michael K. Riscoe,Michael K. Riscoe +21 more
TL;DR: It is revealed that the substitution pattern on the benzenoid ring of the quinolone core significantly influenced reactivity with the host enzyme, which led to the rational design of highly selective ELQs with outstanding oral efficacy against murine malaria that is superior to established antimalarials chloroquine and atovaquone.
Journal ArticleDOI
Comparative antimalarial activities and ADME profiles of ozonides (1,2,4-trioxolanes) OZ277, OZ439, and their 1,2-dioxolane, 1,2,4-trioxane, and 1,2,4,5-tetraoxane isosteres.
Xiaofang Wang,Yuxiang Dong,Sergio Wittlin,Sergio Wittlin,Susan A. Charman,Francis C. K. Chiu,Jacques Chollet,Jacques Chollet,Kasiram Katneni,Janne Mannila,Julia Morizzi,Eileen Ryan,Christian Scheurer,Christian Scheurer,Jessica Anne Steuten,Josefina Santo Tomas,Josefina Santo Tomas,Christopher Snyder,Christopher Snyder,Jonathan L. Vennerstrom +19 more
TL;DR: In this article, the antimalarial activities and ADME profiles of the 1,2,4-trioxolane substructure of dispiro ozonides OZ277 and OZ439 were compared.
Journal ArticleDOI
An in vitro toolbox to accelerate anti-malarial drug discovery and development
Susan A. Charman,Alice Andreu,Helena Barker,Scott Blundell,Anna Campbell,Michael Campbell,Gong Chen,Francis C. K. Chiu,Elly Crighton,Kasiram Katneni,Julia Morizzi,Rahul Patil,Thao Pham,Eileen Ryan,Jessica Saunders,David M. Shackleford,Karen L. White,Lisa Almond,Maurice Dickins,Dennis A. Smith,Joerg J. Moehrle,Jeremy N. Burrows,Nada Abla +22 more
TL;DR: This is the first data set to describe in vitro properties for 45 legacy and development anti-malarial drugs and will be a valuable tool for malaria researchers aiming to develop PBPK models for the prediction of human PK properties and/or drug–drug interactions.