J
Jessica Tsonos
Researcher at Vrije Universiteit Brussel
Publications - 5
Citations - 128
Jessica Tsonos is an academic researcher from Vrije Universiteit Brussel. The author has contributed to research in topics: Bacteriophage & Phage therapy. The author has an hindex of 4, co-authored 5 publications receiving 104 citations. Previous affiliations of Jessica Tsonos include Katholieke Universiteit Leuven & Flanders Institute for Biotechnology.
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Journal ArticleDOI
A cocktail of in vitro efficient phages is not a guarantee for in vivo therapeutic results against avian colibacillosis.
Jessica Tsonos,Leon Oosterik,Huruma Nelwike Tuntufye,Huruma Nelwike Tuntufye,Jochen Klumpp,Patrick Butaye,Henri De Greve,Jean-Pierre Hernalsteens,Rob Lavigne,Bruno Goddeeris,Bruno Goddeeris +10 more
TL;DR: The results indicate that the efficiency of the phage cocktail used in treating CH2-infected chickens in vivo is negligible, even though in vitro, the phages in the cocktail were able to efficiently lyse the APEC strain CH2.
Journal ArticleDOI
Hurdles in bacteriophage therapy: Deconstructing the parameters
Jessica Tsonos,Dieter Vandenheuvel,Yves Briers,Henri De Greve,Jean-Pierre Hernalsteens,Rob Lavigne +5 more
TL;DR: This review argues thatphage therapy has not revealed all of its secrets and many parameters remain understudied, making the outcome of phage therapy highly variable depending on the disease incidence, which justifies the need for additional in depth research in this domain.
Journal ArticleDOI
Complete Genome Sequence of the Novel Escherichia coli Phage phAPEC8
Jessica Tsonos,Evelien M. Adriaenssens,Jochen Klumpp,Jean-Pierre Hernalsteens,Rob Lavigne,H. De Greve +5 more
TL;DR: Genomic analysis of the phAPEC8 genome revealed that 53% of the 269 encoded proteins are unique to this phage, which represents a novel, phylogenetically distinct clade within the Myoviridae, with molecular properties suitable for phage therapy applications.
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Structural Analysis of Jumbo Coliphage phAPEC6
Jeroen Wagemans,Jessica Tsonos,Jessica Tsonos,Dominique Holtappels,Kiandro Fortuna,Jean-Pierre Hernalsteens,Henri De Greve,Leandro F. Estrozi,Maria Bacia-Verloop,Christine Moriscot,Jean-Paul Noben,Guy Schoehn,Rob Lavigne +12 more
TL;DR: Cryo-electron microscopy experiments showed that the 350-kbp DNA molecule of Escherichia coli virus phAPEC6 is packaged in at least 15 concentric layers in the phage capsid.
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Bioluminescent avian pathogenic Escherichia coli for monitoring colibacillosis in experimentally infected chickens
Leon Oosterik,Huruma Nelwike Tuntufye,Jessica Tsonos,Tom Luyten,Sam Noppen,Sandra Liekens,Rob Lavigne,Patrick Butaye,Bruno Goddeeris +8 more
TL;DR: It is shown that lux could be used for identification of the infecting strain after experimental infection with APEC in poultry, and there was no effect on virulence in an intratracheal infection model in 1-day-old chicks, although results with a subcutaneous infection model were inconclusive.