J
Jesús Ruberte
Researcher at Autonomous University of Barcelona
Publications - 90
Citations - 3153
Jesús Ruberte is an academic researcher from Autonomous University of Barcelona. The author has contributed to research in topics: Retina & Mesonephros. The author has an hindex of 25, co-authored 88 publications receiving 2595 citations. Previous affiliations of Jesús Ruberte include University of Lisbon & Carlos III Health Institute.
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Journal ArticleDOI
Programmed Cell Senescence during Mammalian Embryonic Development
Daniel Muñoz-Espín,Marta Cañamero,Antonio Maraver,Gonzalo Gómez-López,Julio Contreras,Julio Contreras,Silvia Murillo-Cuesta,Alfonso Rodríguez-Baeza,Isabel Varela-Nieto,Jesús Ruberte,Manuel Collado,Manuel Serrano +11 more
TL;DR: It is shown that senescence occurs during mammalian embryonic development at multiple locations, including the mesonephros and the endolymphatic sac of the inner ear, and it is proposed that this is the evolutionary origin of damage-inducedsenescence.
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FGF21 gene therapy as treatment for obesity and insulin resistance
Veronica Jimenez,Claudia Jambrina,Estefania Casana,Victor Sacristan,Sergio Muñoz,Sara Darriba,Jordi Rodó,Cristina Mallol,Miquel Garcia,Xavier León,Sara Marcó,Albert Ribera,Ivet Elias,Alba Casellas,Ignasi Grass,Gemma Elias,Tura Ferre,Sandra Motas,Sylvie Franckhauser,Francisca Mulero,Marc Navarro,Virginia Haurigot,Jesús Ruberte,Fatima Bosch +23 more
TL;DR: FGF21 overproduction in healthy animals fed a standard diet prevented the increase in weight and insulin resistance associated with aging and underscores the potential of FGF21 gene therapy to treat obesity, insulin resistance, and T2D.
Journal ArticleDOI
Increased ocular levels of IGF-1 in transgenic mice lead to diabetes-like eye disease
Jesús Ruberte,Eduard Ayuso,Marc Navarro,Ana Carretero,Víctor Nacher,Virginia Haurigot,Mónica George,Cristina Llombart,Alba Casellas,Cristina Costa,Assumpció Bosch,Fatima Bosch +11 more
TL;DR: A role of IGF-1 in the development of ocular complications in long-term diabetes is suggested, as these transgenic mice may be used to study the mechanisms that lead to diabetes eye disease and constitute an appropriate model in which to assay new therapies.
Journal ArticleDOI
Overexpression of Il6 leads to hyperinsulinaemia, liver inflammation and reduced body weight in mice
Sylvie Franckhauser,Ivet Elias,V. Rotter Sopasakis,Tura Ferre,Ivan Nagaev,Christian X. Andersson,Judith Agudo,Jesús Ruberte,Fatima Bosch,Ulf Smith,Ulf Smith +10 more
TL;DR: Chronically elevated IL-6 levels lead to inappropriate hyperinsulinaemia, reduced body weight, impaired insulin-stimulated glucose uptake by the skeletal muscles and marked inflammation in the liver, despite the fact that weight reduction may be expected.
Journal ArticleDOI
Scavenger function of resident autofluorescent perivascular macrophages and their contribution to the maintenance of the blood-retinal barrier.
L Mendes-Jorge,David Ramos,Mariana Luppo,Cristina Llombart,Graça Alexandre-Pires,Víctor Nacher,Verònica Melgarejo,M. Correia,Marc Navarro,Ana Carretero,Sabrina Tafuro,Alfonso Rodríguez-Baeza,José António Esperança-Pina,Fatima Bosch,Jesús Ruberte +14 more
TL;DR: The presence of autofluorescent perivascular macrophages, different from microglia, with a scavenger function that may contribute to the maintenance of the blood-retinal barrier in healthy conditions and that are also involved in retinopathy is shown.