J
Jhanelle Graham
Researcher at National Institutes of Health
Publications - 4
Citations - 531
Jhanelle Graham is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Cognitive development & Micronutrient. The author has an hindex of 4, co-authored 4 publications receiving 403 citations.
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Journal ArticleDOI
The MAL-ED Study: A Multinational and Multidisciplinary Approach to Understand the Relationship Between Enteric Pathogens, Malnutrition, Gut Physiology, Physical Growth, Cognitive Development, and Immune Responses in Infants and Children Up to 2 Years of Age in Resource-Poor Environments
Angel Mendez Acosta,Cesar Banda Chavez,Julian Torres Flores,Maribel Paredes Olotegui,Silvia Rengifo Pinedo,Dixner Rengifo Trigoso,Angel Orbe Vasquez,Imran Ahmed,Didar Alam,Asad Ali,Zulfiqar A Bhutta,Shahida Qureshi,Sadia Shakoor,Sajid Bashir Soofi,Ali Turab,Aisha K. Yousafzai,Anita K. M. Zaidi,Ladaporn Bodhidatta,Carl J. Mason,Sudhir Babji,Anuradha Bose,Sushil John,Gagandeep Kang,Beena Kurien,Jayaprakash Muliyil,Mohan Venkata Raghava,Anup Ramachandran,Anuradha Rose,William Pan,Ramya Ambikapathi,Danny Carreon,Vivek Charu,Leyfou Dabo,Viyada Doan,Jhanelle Graham,Christel Hoest,Stacey Knobler,Dennis Lang,Benjamin J.J. McCormick,Monica McGrath,Mark A. Miller,Archana Mohale,Gaurvika M. L. Nayyar,Stephanie Psaki,Zeba A Rasmussen,Stephanie A. Richard,Jessica C. Seidman,Vivian Ota Wang,Rebecca Blank,Michael Gottlieb,Karen H. Tountas,Caroline Amour,Estomih Mduma,Tahmeed Ahmed,AM Shamsir Ahmed,Mondol Dinesh,Fahmida Tofail,Rashidul Haque,Iqbal Hossain,M Munirul Islam,Mustafa Mahfuz,Ram Krishna Chandyo,Prakash Shrestha,Rita Shrestha,Manjeswori Ulak,Robert E. Black,Laura E. Caulfield,William Checkley,Ping Chen,Margaret Kosek,Gwenyth O. Lee,Pablo Peñataro Yori,Laura E. Murray-Kolb,Barbara A. Schaefer,Laura L. Pendergast,Cláudia B. Abreu,Alexandre Havt Bindá,H. Costa,Alessandra Di Moura,José Q. Filho,Álvaro M. Leite,Aldo A. M. Lima,Noélia L. Lima,Ila F. N. Lima,Bruna Leal Lima Maciel,Milena Lima de Moraes,Francisco Suetônio Bastos Mota,Reinaldo B. Oriá,Josiane da Silva Quetz,Alberto M. Soares,Erling Svensen,Strand Tor,Crystal L. Patil,Pascal O. Bessong,Cloupas Mahopo,Angelina Mapula,Cebisa Nesamvuni,Emanuel Nyathi,Amidou Samie,Leah J. Barrett,Jean Gratz,Richard Guerrant,Eric R. Houpt,Liz Olmsted,William A. Petri,James A Platts-Mills,Rebecca J. Scharf,Binob Shrestha,Sanjaya K. Shrestha +108 more
TL;DR: The hypothesis is that enteropathogen infection contributes to undernutrition by causing intestinal inflammation and/or by altering intestinal barrier and absorptive function, and it is further postulated that this leads to growth faltering and deficits in cognitive development.
Journal ArticleDOI
Causal Pathways from Enteropathogens to Environmental Enteropathy: Findings from the MAL-ED Birth Cohort Study.
Margaret Kosek,Tahmeed Ahmed,Zulfiquar Bhutta,Laura E. Caulfield,Richard Guerrant,Eric R. Houpt,Gagandeep Kang,Margaret Kosek,Gwenyth O. Lee,Aldo A. M. Lima,Benjamin J.J. McCormick,James A Platts-Mills,Jessica C. Seidman,Rebecca R. Blank,Michael Gottlieb,Stacey Knobler,Dennis Lang,Mark A. Miller,Karen H. Tountas,Zulfiqar A Bhutta,William Checkley,William Checkley,Richard L. Guerrant,Carl J. Mason,Laura E. Murray-Kolb,William A. Petri,Jessica C. Seidman,Pascal O. Bessong,Rashidul Haque,Sushil John,Aldo Am Lima,Estomih Mduma,Reinaldo B. Oriá,Prakash S. Shrestha,Sanjaya K. Shrestha,Erling Svensen,Erling Svensen,Anita K. M. Zaidi,Cláudia B. Abreu,Angel Mendez Acosta,Imran Ahmed,AM Shamsir Ahmed,Asad Ali,Ramya Ambikapathi,Leah J. Barrett,Aubrey Bauck,Eliwaza Bayyo,Ladaporn Bodhidatta,Anuradha Bose,J. Daniel Carreon,Ram Krishna Chandyo,Vivek Charu,H. Costa,Rebecca Dillingham,Alessandra Di Moura,Viyada Doan,José Q. Filho,José Q. Filho,Jhanelle Graham,Christel Hoest,Iqbal Hossain,M Munirul Islam,M. Steffi Jennifer,Shiny Kaki,Beena Koshy,Álvaro M. Leite,Noélia L. Lima,Bruna L L Maciel,Mustafa Mahfuz,Cloupas Mahopo,Angelina Maphula,Monica McGrath,Archana Mohale,Milena Lima de Moraes,Francisco Suetônio Bastos Mota,Jayaprakash Muliyil,Regisiana Mvungi,Gaurvika M. L. Nayyar,Emanuel Nyathi,Maribel Paredes Olortegui,Reinaldo Oria,Angel Orbe Vasquez,William Pan,William Pan,John M. Pascal,Crystal L. Patil,Laura L. Pendergast,Silvia Rengifo Pinedo,Stephanie Psaki,Mohan Venkata Raghava,Karthikeyan Ramanujam,Muneera A. Rasheed,Zeba A Rasmussen,Stephanie A. Richard,Anuradha Rose,Reeba Roshan,Barbara A. Schaefer,Barbara A. Schaefer,Rebecca J. Scharf,Srujan Lam Sharma,Binob Shrestha,Rita Shrestha,Suzanne Simons,Alberto M. Soares,Rosa Maria Salani Mota,Sajid Bashir Soofi,Tor A. Strand,Tor A. Strand,Fahmida Tofail,Rahul J. Thomas,Ali Turab,Manjeswori Ulak,Vivian Ota Wang,Ladislaus Blacy Yarrot,Pablo Peñataro Yori,Didar Alam,Caroline Amour,Cesar Banda Chavez,Sudhir Babji,Rosa Burga,Julian Torres Flores,Jean Gratz,Ajila T. George,Dinesh Hariraju,Alexandre Havt,Priyadarshani Karunakaran,Robin P. Lazarus,Ila F. N. Lima,Dinesh Mondal,Pedro H. Q. S. Medeiros,Rosemary Nshama,Josiane da Silva Quetz,Shahida Qureshi,Sophy Raju,Anup Ramachandran,Rakhi Ramadas,A. Catharine Ross,Mery Siguas Salas,Amidou Samie,Kerry Schulze,E. Shanmuga Sundaram,Buliga Mujaga Swema,Dixner Rengifo Trigoso +142 more
TL;DR: The MAL-ED study represents a novel analytical framework and explicitly evaluates multiple putative EE pathways in combination and using an unprecedented quantity of data to demonstrate that enteric infection alters both fecal markers of inflammation and permeability.
Early childhood cognitive development is affected by interactions among illness, diet, enteropathogens and the home environment: Findings from the MAL-ED birth cohort study
Laura E. Murray-Kolb,Angel Mendez Acosta,RR De Burga,Cesar Banda Chavez,Julian Torres Flores,Maribel Paredes Olotegui,Pinedo,Salas,Trigoso,Angel Orbe Vasquez,Imran Ahmed,Dewan S. Alam,Asad Ali,Zulfiqar A Bhutta,Shahida Qureshi,Muneera A. Rasheed,Sajid Bashir Soofi,Ali Turab,Akm Zaidi,Ladaporn Bodhidatta,Carl J. Mason,Sudhir Babji,Anuradha Bose,Ajila T. George,Dinesh Hariraju,Jennifer,Sushil John,Shiny Kaki,Gagandeep Kang,Priyadarshani Karunakaran,Beena Koshy,Robin P. Lazarus,Jayaprakash Muliyil,Mohan Venkata Raghava,Sophy Raju,Anup Ramachandran,Rakhi Ramadas,Karthikeyan Ramanujam,Reeba Roshan,Srujan Lam Sharma,Shanmuga Sundaram,Rahul J. Thomas,William Pan,Ramya Ambikapathi,JD Carreon,Charu,Doan,Jhanelle Graham,Christel Hoest,Stacey Knobler,Lang,Bjj McCormick,Monica McGrath,Mark A. Miller,Archana Mohale,Gaurvika M. L. Nayyar,Stephanie Psaki,Zeba A Rasmussen,Stephanie A. Richard,Jessica C. Seidman,Wang,Rebecca Blank,Michael Gottlieb,Karen H. Tountas,Caroline Amour,Eliwaza Bayyo,Estomih R. Mduma,Regisiana Mvungi,Rosemary Nshama,John M. Pascal,Buliga Mujaga Swema,Ladislaus Blacy Yarrot,Tahmeed Ahmed,Ams Ahmed,Rashidul Haque,Iqbal Hossain,M Munirul Islam,Mustafa Mahfuz,Dinesh Mondal,Fahmida Tofail,Ram Krishna Chandyo,Prakash Shrestha,Rita Shrestha,Manjeswori Ulak,Aubrey Bauck,Robert E. Black,Laura E. Caulfield,William Checkley,Margaret Kosek,Gwenyth O. Lee,Kerry Schulze,Pablo Peñataro Yori,A. Catharine Ross,Barbara A. Schaefer,Suzanne Simons,Laura L. Pendergast,Cláudia B. Abreu,H. Costa +97 more
Journal ArticleDOI
Intestinal permeability and inflammation mediate the association between nutrient density of complementary foods and biochemical measures of micronutrient status in young children: results from the MAL-ED study.
Benjamin J.J. McCormick,Laura E. Murray-Kolb,Gwenyth O. Lee,Kerry Schulze,A. Catharine Ross,Aubrey Bauck,Aldo A. M. Lima,Bruna Leal Lima Maciel,Margaret Kosek,Jessica C. Seidman,Ramya Ambikapathi,Anuradha Bose,Sushil John,Gagandeep Kang,Ali Turab,Estomih Mduma,Pascal O. Bessong,Sanjaya K. Shrestra,Tahmeed Ahmed,Mustafa Mahfuz,Maribel Paredes Olortegui,Zulfiqar A Bhutta,Laura E. Caulfield,Angel Mendez Acosta,Rosa Burga,Cesar Banda Chavez,Julian Torres Flores,Maribel Paredes Olotegui,Silvia Rengifo Pinedo,Mery Siguas Salas,Dixner Rengifo Trigoso,Angel Orbe Vasquez,Imran Ahmed,Didar Alam,Asad Ali,Zulfiqar A. Bhutta,Shahida Qureshi,Muneera A. Rasheed,Sajid Bashir Soofi,Anita K. M. Zaidi,Ladaporn Bodhidatta,Carl J. Mason,Sudhir Babji,Ajila T. George,Dinesh Hariraju,M. Steffi Jennifer,Shiny Kaki,Priyadarshani Karunakaran,Beena Koshy,Robin P. Lazarus,Jayaprakash Muliyil,Mohan Venkata Raghava,Sophy Raju,Anup Ramachandran,Rakhi Ramadas,Karthikeyan Ramanujam,Reeba Roshan,Srujan Lam Sharma,Shanmuga Sundaram,Rahul J. Thomas,William Pan,William Pan,J. Daniel Carreon,Vivek Charu,Viyada Doan,Jhanelle Graham,Christel Hoest,Stacey Knobler,Dennis Lang,Monica McGrath,Mark A. Miller,Archana Mohale,Gaurvika M. L. Nayyar,Stephanie Psaki,Zeba A Rasmussen,Stephanie A. Richard,Vivian Ota Wang,Rebecca Blank,Michael Gottlieb,Karen H. Tountas,Caroline Amour,Eliwaza Bayyo,Estomih R. Mduma,Regisiana Mvungi,Rosemary Nshama,John M. Pascal,Buliga Mujaga Swema,Ladislaus Blacy Yarrot,AM Shamsir Ahmed,Rashidul Haque,Iqbal Hossain,M Munirul Islam,Dinesh Mondal,Fahmida Tofail,Ram Krishna Chandyo,Prakash S. Shrestha,Rita Shrestha,Manjeswori Ulak,Robert E. Black,William Checkley,William Checkley,Pablo Peñataro Yori,Barbara A. Schaefer,Barbara A. Schaefer,Suzanne Simons,Laura L. Pendergast,Cláudia B. Abreu,H. Costa,Alessandra Di Moura,José Q. Filho,José Q. Filho,Alexandre Havt,Álvaro M. Leite,Noélia L. Lima,Ila F. N. Lima,Pedro H. Q. S. Medeiros,Milena Lima de Moraes,Francisco Suetônio Bastos Mota,Reinaldo B. Oriá,Josiane da Silva Quetz,Alberto M. Soares,Rosa Maria Salani Mota,Crystal L. Patil,Cloupas Mahopo,Angelina Maphula,Emanuel Nyathi,Amidou Samie,Leah J. Barrett,Rebecca Dillingham,Jean Gratz,Richard L. Guerrant,Eric R. Houpt,William A. Petri,James A Platts-Mills,Rebecca J. Scharf,Binob Shrestha,Sanjaya K. Shrestha,Tor A. Strand,Erling Svensen,Erling Svensen +139 more
TL;DR: Inverse associations between nutrient densities and micronutrient deficiency largely disappeared after adjustment for EED, suggesting that EED mediates these associations.