Causal Pathways from Enteropathogens to Environmental Enteropathy: Findings from the MAL-ED Birth Cohort Study.
Margaret Kosek,Tahmeed Ahmed,Zulfiquar Bhutta,Laura E. Caulfield,Richard Guerrant,Eric R. Houpt,Gagandeep Kang,Margaret Kosek,Gwenyth O. Lee,Aldo A. M. Lima,Benjamin J.J. McCormick,James A Platts-Mills,Jessica C. Seidman,Rebecca R. Blank,Michael Gottlieb,Stacey Knobler,Dennis Lang,Mark A. Miller,Karen H. Tountas,Zulfiqar A Bhutta,William Checkley,William Checkley,Richard L. Guerrant,Carl J. Mason,Laura E. Murray-Kolb,William A. Petri,Jessica C. Seidman,Pascal O. Bessong,Rashidul Haque,Sushil John,Aldo Am Lima,Estomih Mduma,Reinaldo B. Oriá,Prakash S. Shrestha,Sanjaya K. Shrestha,Erling Svensen,Erling Svensen,Anita K. M. Zaidi,Cláudia B. Abreu,Angel Mendez Acosta,Imran Ahmed,AM Shamsir Ahmed,Asad Ali,Ramya Ambikapathi,Leah J. Barrett,Aubrey Bauck,Eliwaza Bayyo,Ladaporn Bodhidatta,Anuradha Bose,J. Daniel Carreon,Ram Krishna Chandyo,Vivek Charu,H. Costa,Rebecca Dillingham,Alessandra Di Moura,Viyada Doan,José Q. Filho,José Q. Filho,Jhanelle Graham,Christel Hoest,Iqbal Hossain,M Munirul Islam,M. Steffi Jennifer,Shiny Kaki,Beena Koshy,Álvaro M. Leite,Noélia L. Lima,Bruna L L Maciel,Mustafa Mahfuz,Cloupas Mahopo,Angelina Maphula,Monica McGrath,Archana Mohale,Milena Lima de Moraes,Francisco Suetônio Bastos Mota,Jayaprakash Muliyil,Regisiana Mvungi,Gaurvika M. L. Nayyar,Emanuel Nyathi,Maribel Paredes Olortegui,Reinaldo Oria,Angel Orbe Vasquez,William Pan,William Pan,John M. Pascal,Crystal L. Patil,Laura L. Pendergast,Silvia Rengifo Pinedo,Stephanie Psaki,Mohan Venkata Raghava,Karthikeyan Ramanujam,Muneera A. Rasheed,Zeba A Rasmussen,Stephanie A. Richard,Anuradha Rose,Reeba Roshan,Barbara A. Schaefer,Barbara A. Schaefer,Rebecca J. Scharf,Srujan Lam Sharma,Binob Shrestha,Rita Shrestha,Suzanne Simons,Alberto M. Soares,Rosa Maria Salani Mota,Sajid Bashir Soofi,Tor A. Strand,Tor A. Strand,Fahmida Tofail,Rahul J. Thomas,Ali Turab,Manjeswori Ulak,Vivian Ota Wang,Ladislaus Blacy Yarrot,Pablo Peñataro Yori,Didar Alam,Caroline Amour,Cesar Banda Chavez,Sudhir Babji,Rosa Burga,Julian Torres Flores,Jean Gratz,Ajila T. George,Dinesh Hariraju,Alexandre Havt,Priyadarshani Karunakaran,Robin P. Lazarus,Ila F. N. Lima,Dinesh Mondal,Pedro H. Q. S. Medeiros,Rosemary Nshama,Josiane da Silva Quetz,Shahida Qureshi,Sophy Raju,Anup Ramachandran,Rakhi Ramadas,A. Catharine Ross,Mery Siguas Salas,Amidou Samie,Kerry Schulze,E. Shanmuga Sundaram,Buliga Mujaga Swema,Dixner Rengifo Trigoso +142 more
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TLDR
The MAL-ED study represents a novel analytical framework and explicitly evaluates multiple putative EE pathways in combination and using an unprecedented quantity of data to demonstrate that enteric infection alters both fecal markers of inflammation and permeability.About:
This article is published in EBioMedicine.The article was published on 2017-04-01 and is currently open access. It has received 171 citations till now. The article focuses on the topics: Environmental enteropathy & Systemic inflammation.read more
Citations
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Journal ArticleDOI
Environmental enteric dysfunction pathways and child stunting: A systematic review.
TL;DR: It is suggested that certain EED biomarkers may require reconsideration, particularly those most difficult to measure, such as microbial translocation and intestinal permeability, because of the lack of evidence of relationships among domains and between each domain with stunting.
Journal ArticleDOI
Stunted childhood growth is associated with decompartmentalization of the gastrointestinal tract and overgrowth of oropharyngeal taxa.
Pascale Vonaesch,Pascale Vonaesch,Evan Morien,Lova Andrianonimiadana,Hugues Sanke,Jean-Robert Mbecko,Kelsey E. Huus,Tanteliniaina Naharimanananirina,Bolmbaye Privat Gondje,Synthia Nazita Nigatoloum,Sonia Sandrine Vondo,Jepthé Estimé Kaleb Kandou,Rindra Randremanana,Maheninasy Rakotondrainipiana,Florent Mazel,Serge Ghislain Djorie,Jean-Chrysostome Gody,B. Brett Finlay,Pierre-Alain Rubbo,Laura Wegener Parfrey,Jean-Marc Collard,Philippe J. Sansonetti,Philippe J. Sansonetti,Philippe J. Sansonetti +23 more
TL;DR: The data suggest that stunting is associated with a microbiome “decompartmentalization” of the gastrointestinal tract characterized by an increased presence of oropharyngeal bacteria from the stomach to the colon, hence challenging the current view of stunting arising solely as a consequence of small intestine overstimulation through recurrent infections by enteric pathogens.
Journal ArticleDOI
Stunting in childhood: an overview of global burden, trends, determinants, and drivers of decline.
Tyler Vaivada,Nadia Akseer,Selai Akseer,Ahalya Somaskandan,Marianne Stefopulos,Zulfiqar A Bhutta,Zulfiqar A Bhutta +6 more
TL;DR: Unique sets of stunting determinants predicted stunting reduction within countries that have reduced stunting, and several common drivers emerge at the basic, underlying, and immediate levels, including improvements in maternal and paternal education, household socioeconomic status, sanitation conditions, maternal health services access, and family planning.
Journal ArticleDOI
Relationship between growth and illness, enteropathogens and dietary intakes in the first 2 years of life: findings from the MAL-ED birth cohort study
TL;DR: Reducing enteropathogen burden and improving energy and protein density of complementary foods could reduce stunting.
Journal ArticleDOI
Environmental enteric dysfunction and child stunting.
TL;DR: The existing literature surrounding the proposed pathology and transmission of EED in infants and considerations for nutrition and WASH interventions to improve linear growth worldwide are reviewed.
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