J
Jia Li
Researcher at University of Rochester
Publications - 84
Citations - 1021
Jia Li is an academic researcher from University of Rochester. The author has contributed to research in topics: Internal medicine & Click chemistry. The author has an hindex of 20, co-authored 76 publications receiving 892 citations. Previous affiliations of Jia Li include Chinese Academy of Sciences & Oakland University.
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Spectroscopic and phosphorescent modulation in triphosphine-supported PtAg2 heterotrinuclear alkynyl complexes.
TL;DR: Both experimental and time-dependent density functional theory (TD-DFT) studies demonstrate that d(8)-d(10) metallophilic interaction exerts a crucial role on phosphorescent characteristics due to the PtAg2 cluster-based (3)[d → p] state.
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Cembrane diterpenoids from the soft coral Sarcophyton trocheliophorum Marenzeller as a new class of PTP1B inhibitors.
TL;DR: Some of the isolated compounds showed significant inhibitory activity against human protein tyrosine phosphatase 1B (PTP1B) enzyme, a key target for the treatment of type-II diabetes and obesity, and some preliminary structure-activity relationships have been drawn.
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A novel class of small-molecule caspase-3 inhibitors prepared by multicomponent reactions
TL;DR: The most active compounds 5k (IC(50) = 5.27 μM) could therefore be used as a lead for the development of highly potent caspase-3 inhibitors as drug candidates for therapeutic agents by taking advantage of MCRs.
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Sarsolenane and Capnosane Diterpenes from the Hainan Soft Coral Sarcophyton trocheliophorum Marenzeller as PTP1B Inhibitors
TL;DR: Two new sarsolenane diterpenes, sarsolilides B (5) and C (6), were isolated from the Hainan soft coral Sarcophyton trocheliophorum Marenzeller as mentioned in this paper.
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Expeditious preparation of triazole-linked glycolipids via microwave accelerated click chemistry and their electrochemical and biological assessments
Shao-Xing Song,Hai-Lin Zhang,Chol-Guk Kim,Li Sheng,Xiao-Peng He,Xiao-Peng He,Yi-Tao Long,Jia Li,Guo-Rong Chen +8 more
TL;DR: A series of triazole-linked ester-type glycolipids were efficiently prepared via a two-step sequence involving microwave accelerated "click" chemistry and debenzylation as discussed by the authors.