J
Jia Yao Phuah
Researcher at University of Pittsburgh
Publications - 17
Citations - 1492
Jia Yao Phuah is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Mycobacterium tuberculosis & Tuberculosis. The author has an hindex of 11, co-authored 16 publications receiving 1161 citations. Previous affiliations of Jia Yao Phuah include University of Massachusetts Medical School.
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Journal ArticleDOI
Variability in tuberculosis granuloma T cell responses exists, but a balance of pro- and anti-inflammatory cytokines is associated with sterilization.
Hannah P. Gideon,Jia Yao Phuah,Amy J. Myers,Bryan D. Bryson,Mark Rodgers,M. Teresa Coleman,Pauline Maiello,Tara Rutledge,Simeone Marino,Sarah M. Fortune,Denise E. Kirschner,Philana Ling Lin,JoAnne L. Flynn +12 more
TL;DR: The results support that each granuloma within an individual host is independent with respect to total cell numbers, proportion of T cells, pattern of cytokine response, and bacterial burden, and the spectrum of these components overlaps greatly amongst animals with different clinical status.
Journal ArticleDOI
Phosphotyrosine-dependent coupling of Tim-3 to T-cell receptor signaling pathways.
Judong Lee,Ee Wern Su,Chen Zhu,Sarah G. Hainline,Jia Yao Phuah,Jamie A. Moroco,Thomas E. Smithgall,Vijay K. Kuchroo,Lawrence P. Kane +8 more
TL;DR: It is demonstrated that two of the more membrane-proximal cytoplasmic tail tyrosines are required for Tim-3 signaling to T-cell activation pathways in a redundant fashion and Tim-2 can directly bind to the Src family tyrosine kinase Fyn and the p85 phosphatidylinositol 3-kinase (PI3K) adaptor.
Journal ArticleDOI
Nitric oxide prevents a pathogen-permissive granulocytic inflammation during tuberculosis.
Bibhuti B. Mishra,Rustin R. Lovewell,Andrew J. Olive,Guoliang Zhang,Wenfei Wang,Eliseo A. Eugenin,Clare M. Smith,Jia Yao Phuah,Jarukit E. Long,Michelle L. Dubuke,Samantha G. Palace,Jon D. Goguen,Richard Baker,Subhalaxmi Nambi,Rabinarayan Mishra,Matthew G. Booty,Christina E. Baer,Scott A. Shaffer,Véronique Dartois,Beth A. McCormick,Xinchun Chen,Christopher M. Sassetti +21 more
TL;DR: The data suggest that M. tuberculosis exploits neutrophilic inflammation to preferentially replicate at sites of tissue damage that promote contagion, and that a similar inflammatory pathway promotes tuberculosis in patients.
Journal ArticleDOI
Reactivation of latent tuberculosis in cynomolgus macaques infected with SIV is associated with early peripheral T cell depletion and not virus load.
Collin R. Diedrich,Joshua T. Mattila,Edwin Klein,Chris Janssen,Jia Yao Phuah,Timothy J. Sturgeon,Ronald C. Montelaro,Philana Ling Lin,JoAnne L. Flynn +8 more
TL;DR: Initial T cell depletion may strongly influence outcomes of HIV-Mtb co-infection in HIV-infected humans, and granulomas from these animals demonstrated histopathologic characteristics consistent with a chronically active disease process.
Journal ArticleDOI
Tuberculosis Susceptibility and Vaccine Protection Are Independently Controlled by Host Genotype
Clare M. Smith,Megan K. Proulx,Andrew J. Olive,Dominick Laddy,Bibhuti B. Mishra,Caitlin E Moss,Nuria Martinez Gutierrez,Michelle M. Bellerose,Palmira Barreira-Silva,Jia Yao Phuah,Richard Baker,Samuel M. Behar,Hardy Kornfeld,Thomas G. Evans,Gillian Beamer,Christopher M. Sassetti +15 more
TL;DR: A model system that captures the breadth of immunological responses observed in outbred individual mice can be used to understand the contribution of host genetics to vaccine efficacy and provide a model system to develop interventions that will be useful in genetically diverse populations.