Showing papers by "Jiajia Xue published in 2021"
TL;DR: The future direction of the design and functionalization of electroactive electrospun nanofibers for tissue engineering, and several promising strategies to make the scaffolds more intelligent, portable, monitorable, and safe are focused on.
92 citations
01 Sep 2021
TL;DR: In this article, the authors present representative material strategies for applying nanoplatforms for treating bone diseases based on a deeper knowledge of the biophysical structure and material-chemical composition of human osteology, and the awareness of disease pathogenesis and progression.
Abstract: Summary Owing to the high density of bone tissue and the complex and highly hierarchical structure, drugs used for the treatment of bone-related diseases are often not effectively concentrated at the site of the lesion. Generally, the therapeutic effect is unsatisfactory, and the long-term use of drugs causes adverse effects. Therefore, it is of great importance to explore nanotherapeutic platforms to improve bone-targeting capabilities and provide controlled release performance on demand to enhance therapeutic effects. This review aims to (1) summarize various types of recently developed nanotherapeutic platforms; (2) present representative material strategies for applying nanoplatforms for treating bone diseases based on a deeper knowledge of the biophysical structure and material-chemical composition of human osteology, and the awareness of disease pathogenesis and progression; and (3) summarize the typical multifunctional systems through a suitable combination of different cues for enhancing the treatment efficacy.
38 citations
TL;DR: The multifunctional 1D FDP nanoplatform with pH-responsive degradability provides a promising candidate to realize enhanced gene/photothermal/magnetolytic therapy in vitro and in vivo.
28 citations
TL;DR: A system comprised of electrospun quad-axial nanofibers fabricated by quadriaxial electrospinning, with the material components in the different layers can be well regulated, representing a promising controlled drug release system.
23 citations
TL;DR: Wang et al. as mentioned in this paper constructed a biomimetic apatite interface on electrospun polycaprolactone fibers by combining layer-by-layer nanocoating with mineralization to fabricate an osteoinductive artificial scaffold.
12 citations
TL;DR: In this article, a photo-thermochromic film can automatically switch between a colored and colorless state in response to climate temperature and light to realize photothermal heating and cooling.
2 citations
TL;DR: In this paper, the authors explored the alterations of the cortical-striatal network in HFS using resting-state functional magnetic resonance imaging (fMRI) data and evaluated the correlation between abnormal FC and severity of hemifacial spasm by Spearman correlation analysis.
Abstract: Objective: Hemifacial spasm (HFS) is a kind of motor disorder, and the striatum plays a significant role in motor function. The purpose of this study is to explore the alterations of the cortical-striatal network in HFS using resting-state functional magnetic resonance imaging (fMRI). Methods: The fMRI data of 30 adult patients with primary unilateral HFS (15 left-side, 15 right-side) and 30 healthy controls were collected. Six subregions of the striatum in each hemisphere were selected for functional connectivity (FC) analysis. One-sample t test was used to analyze the intra-group FC of the HFS group and the control group. Two-sample t test was used to compare the difference of FC between the two groups. The correlation between the abnormal FC and severity of hemifacial spasm was evaluated by Spearman correlation analysis. Results: Compared to the controls, the striatal subregions had altered FC with motor and orbitofrontal cortex in HFS patients, respectively. The altered FC between striatal subregions and motor cortex was correlated with the spasm severity in HFS patients. Conclusions: The FC of the cortical-striatal network was altered in primary HFS, and these alterations were correlated with the severity of hemifacial spasm. This study indicated that the cortical-striatal network may play different roles in the underlying pathological mechanism of HFS.
2 citations