J
Jian Dong Li
Researcher at Georgia State University
Publications - 101
Citations - 6582
Jian Dong Li is an academic researcher from Georgia State University. The author has contributed to research in topics: Mucin & Signal transduction. The author has an hindex of 43, co-authored 101 publications receiving 6079 citations. Previous affiliations of Jian Dong Li include Osaka University & University of Rochester Medical Center.
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Journal ArticleDOI
Activation of NF-κB via a Src-dependent Ras-MAPK-pp90rsk pathway is required for Pseudomonas aeruginosa-induced mucin overproduction in epithelial cells
TL;DR: It is shown that P. aeruginosa activates a c-Src-Ras-MEK1/2-MAPK-pp90rsk signaling pathway that leads to activation of nuclear factor NF-kappaB (p65/p50), which binds to a kappaB site in the 5'-flanking region of the M UC2 gene and activates MUC2 mucin transcription and opens up new therapeutic targets for cystic fibrosis.
Journal ArticleDOI
Transcriptional activation of mucin by Pseudomonas aeruginosa lipopolysaccharide in the pathogenesis of cystic fibrosis lung disease
Jian Dong Li,Austin F. Dohrman,Marianne Gallup,Susumu Miyata,James R. Gum,Young S. Kim,Jay A. Nadel,Alice Prince,Carol Basbaum +8 more
TL;DR: It is shown that P. aeruginosa lipopolysaccharide profoundly upregulates transcription of the mucin gene MUC 2 in epithelial cells via inducible enhancer elements and that this effect is blocked by the tyrosine kinase inhibitors genistein and tyr-phostin AG 126.
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Activation of NF-κB by nontypeable Hemophilus influenzae is mediated by toll-like receptor 2-TAK1-dependent NIK–IKKα/β–IκBα and MKK3/6–p38 MAP kinase signaling pathways in epithelial cells
Tsuyoshi Shuto,Haidong Xu,Haidong Xu,Beinan Wang,Beinan Wang,Jiahuai Han,Hirofumi Kai,Xin Xing Gu,Timothy F. Murphy,David J. Lim,Jian Dong Li,Jian Dong Li +11 more
TL;DR: The results demonstrate that NTHi activates NF-κB via TLR2–TAK1-dependent NIK–IKKα/β-IκBα and MKK3/6–p38 MAP kinase signaling pathways, and several key inflammatory mediators including IL-1β, IL-8, and tumor necrosis factor-α are up-regulated by N THi.
Journal ArticleDOI
Mucin gene (MUC 2 and MUC 5AC) upregulation by Gram-positive and Gram-negative bacteria.
Austin F. Dohrman,Susumu Miyata,Marianne Gallup,Jian Dong Li,C. Chapelin,André Coste,Estelle Escudier,Jay A. Nadel,Carol Basbaum +8 more
TL;DR: Results from in situ hybridization and RNase protection assays showed that P. aeruginosa upregulates MUC 5AC as well as MUC 2 in both bronchial explants and cultured airway epithelial cells, indicating the existence of a general mechanism by which epithelial Cells respond to the presence of bacteria by increasing mucin synthesis.
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Vitamin D receptor negatively regulates bacterial-stimulated NF-κB activity in intestine
TL;DR: It is demonstrated that commensal and pathogenic bacteria directly regulate colonic epithelial VDR expression and location in vivo and VDR negatively regulates bacterial-induced intestinal NF-kappaB activation and attenuates response to infection.