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Shaoping Wu
Researcher at Rush University Medical Center
Publications - 61
Citations - 3173
Shaoping Wu is an academic researcher from Rush University Medical Center. The author has contributed to research in topics: Calcitriol receptor & Vitamin D and neurology. The author has an hindex of 28, co-authored 52 publications receiving 2518 citations. Previous affiliations of Shaoping Wu include Academy of Military Medical Sciences & Chinese Center for Disease Control and Prevention.
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Journal ArticleDOI
Intestinal epithelial vitamin D receptor deletion leads to defective autophagy in colitis
Shaoping Wu,Yong Guo Zhang,Rong Lu,Yinglin Xia,David Zhou,Elaine O. Petrof,Erika C. Claud,Di Chen,Eugene B. Chang,Geert Carmeliet,Jun Sun +10 more
TL;DR: Fundamental relationship between VDR, autophagy and gut microbial assemblage that is essential for maintaining intestinal homeostasis, but also in contributing to the pathophysiology of IBD is demonstrated.
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Vitamin D receptor negatively regulates bacterial-stimulated NF-κB activity in intestine
TL;DR: It is demonstrated that commensal and pathogenic bacteria directly regulate colonic epithelial VDR expression and location in vivo and VDR negatively regulates bacterial-induced intestinal NF-kappaB activation and attenuates response to infection.
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Lack of Vitamin D Receptor Causes Dysbiosis and Changes the Functions of the Murine Intestinal Microbiome
TL;DR: Several important pathways, such as nucleotide-binding oligomerization domain-like receptor, affected by VDR status are identified, including amino acid, carbohydrate, and fatty acid synthesis and metabolism, detoxification, infections, signal transduction, and cancer and other diseases.
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Salmonella‐infected crypt‐derived intestinal organoid culture system for host–bacterial interactions
TL;DR: It is demonstrated that the Salmonella‐infected organoid culture system is a new experimental model suitable for studying host–bacterial interactions and the inflammatory responses through activation of the NF‐κB pathway in the organoids.
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Leaky intestine and impaired microbiome in an amyotrophic lateral sclerosis mouse model
TL;DR: A potential novel role of the intestinal epithelium and microbiome in the progression of ALS is suggested and principal coordinate analysis indicated a difference in fecal microbial communities between ALS and wild‐type mice.