J
Jian Ouyang
Researcher at Harvard University
Publications - 32
Citations - 2326
Jian Ouyang is an academic researcher from Harvard University. The author has contributed to research in topics: Medicine & DNA damage. The author has an hindex of 15, co-authored 21 publications receiving 1746 citations. Previous affiliations of Jian Ouyang include Tufts University & Rockefeller University.
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Direct binding of CoREST1 to SUMO-2/3 contributes to gene-specific repression by the LSD1/CoREST1/HDAC complex.
Jian Ouyang,Yujiang Shi,Yujiang Shi,Alvaro Valin,Alvaro Valin,Yan Xuan,Grace Gill,Grace Gill +7 more
TL;DR: The results reveal that direct interactions between CoREST1 and SUMO-2 mediatesumO-dependent changes in chromatin structure and transcription that are important for cell-type-specific gene expression.
Journal ArticleDOI
SUMO engages multiple corepressors to regulate chromatin structure and transcription.
Jian Ouyang,Grace Gill +1 more
TL;DR: Findings suggest that SUMOylation plays a central role in coordinating histone modifications and chromatin structure important for regulation of gene expression.
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ATR Protects the Genome against R Loops through a MUS81-Triggered Feedback Loop.
TL;DR: It is shown that cells harboring high levels of R loops rely on the ATR kinase for survival, and ATR protects the genome from R loops by suppressing transcription-replication collisions, promoting replication fork recovery, and enforcing a G2/M cell-cycle arrest.
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m5C modification of mRNA serves a DNA damage code to promote homologous recombination.
Hao Chen,Haibo Yang,Xiaolan Zhu,Tribhuwan Yadav,Jian Ouyang,Samuel S. Truesdell,Jun Tan,Yumin Wang,Yumin Wang,Meihan Duan,Leizhen Wei,Lee Zou,Arthur S. Levine,Shobha Vasudevan,Li Lan,Li Lan +15 more
TL;DR: Results reveal an unexpected TRDMT1-m5C axis that promotes HR, suggesting that post-transcriptional modifications of RNA can also serve as DNA damage codes to regulate DNA repair, and facilitate the recruitment of DNA repair factors.
Journal ArticleDOI
Noncovalent interactions with SUMO and ubiquitin orchestrate distinct functions of the SLX4 complex in genome maintenance
Jian Ouyang,Elizabeth Garner,Alexander Hallet,Hai Dang Nguyen,Kimberly A. Rickman,Grace Gill,Agata Smogorzewska,Lee Zou +7 more
TL;DR: The interactions ofSLX4 with SUMO and ubiquitin increase its affinity for factors recognizing different DNA lesions or telomeres, helping to direct the SLX4 complex in distinct functional contexts.