J
Jian Ouyang
Researcher at Harvard University
Publications - 32
Citations - 2326
Jian Ouyang is an academic researcher from Harvard University. The author has contributed to research in topics: Medicine & DNA damage. The author has an hindex of 15, co-authored 21 publications receiving 1746 citations. Previous affiliations of Jian Ouyang include Tufts University & Rockefeller University.
Papers
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Journal ArticleDOI
RNA transcripts stimulate homologous recombination by forming DR-loops.
Jian Ouyang,Tribhuwan Yadav,Jia-Min Zhang,Haibo Yang,Esther Rheinbay,Hongshan Guo,Hongshan Guo,Daniel A. Haber,Daniel A. Haber,Li Lan,Lee Zou +10 more
TL;DR: In this article, the effect of local transcription on homologous recombination was investigated and it was shown that tethered RNA transcripts stimulate recombination through the formation of DR-loops, intermediate structures that contain both DNA-DNA and DNA-RNA hybrids.
Journal ArticleDOI
SUMOylation of ATRIP potentiates DNA damage signaling by boosting multiple protein interactions in the ATR pathway
Ching Shyi Wu,Jian Ouyang,Eiichiro Mori,Hai Dang Nguyen,Alexandre Maréchal,Alexander Hallet,David J. Chen,Lee Zou +7 more
TL;DR: Fusion of a SUMO2 chain to the ATRIP SUMOylation mutant enhances its interaction with the protein group and partially suppresses its localization and functional defects, revealing that ATRIPsumoylation promotes ATR activation by providing a unique type of protein glue that boosts multiple protein interactions along the ATR pathway.
Journal ArticleDOI
Nek1 kinase associates with ATR–ATRIP and primes ATR for efficient DNA damage signaling
TL;DR: As an ATR-associated kinase, Nek1, enhances the stability and activity of ATR–ATRIP before DNA damage, priming ATR—ATRIP for a robust DNA damage response.
Book ChapterDOI
Regulation of transcription factor activity by SUMO modification.
TL;DR: General strategies to address how post-translational modification by SUMO regulates the activity of a DNA-binding transcription factor are described.
Journal ArticleDOI
Alternative Lengthening of Telomeres is a Self-Perpetuating Process in ALT-Associated PML Bodies
TL;DR: In this paper, a self-perpetuating process of break-induced replication (BIR) at telomeres is investigated, and it is shown that BIR generates replication stress.