Jian Wang

TL;DR: It is found that LCH-7749944, a novel and potent PAK4 inhibitor, effectively suppressed the proliferation of human gastric cancer cells through downregulation ofPAK4/c-Src/EGFR/cyclin D1 pathway.

TL;DR: It is demonstrated that NK not only effectively prevented xylene-induced ear oedema in mice, but also remarkably protected against LPS-induced acute kidney injury in mice through restraining inflammation and oxidative stress, a central player in the initiation and progression of inflammation.

TL;DR: A number of 5-phenylisoxazole-3-carboxylic acid derivatives were synthesized and analyzed for their ability to inhibit xanthine oxidase, and the presence of a cyano group at the 3-position of phenyl moiety turned out to be the preferred substitution pattern.

TL;DR: Lineweaver-Burk plot analysis revealed that representative compound 4f acted as a mixed-type inhibitor for xanthine oxidase, rationalized by its molecular docking into the active site ofxanthine dehydrogenase.

TL;DR: The SAR analyses indicated that compounds with 4-morpholino group at the C-4 position of thieno[3,2-d]pyrimidine moiety exhibited superior activities than compounds bearing chain amino groups, and compounds with mono-methoxy group atThe 3-position or dimethyl groups at the 3,5-position on the terminal phenyl ring were more active.