J
Jianhan Chen
Researcher at University of Massachusetts Amherst
Publications - 107
Citations - 4212
Jianhan Chen is an academic researcher from University of Massachusetts Amherst. The author has contributed to research in topics: Intrinsically disordered proteins & Protein structure. The author has an hindex of 33, co-authored 99 publications receiving 3384 citations. Previous affiliations of Jianhan Chen include Scripps Research Institute & University of Michigan.
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Balancing Solvation and Intramolecular Interactions: Toward a Consistent Generalized Born Force Field
TL;DR: It is demonstrated that it is possible to achieve a balanced implicit solvent force field by further optimizing the input atomic radii in combination with adjusting the protein backbone torsional energetics.
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Power generation from ambient humidity using protein nanowires.
Xiaomeng Liu,Hongyan Gao,Joy E. Ward,Xiaorong Liu,Bing Yin,Tianda Fu,Jianhan Chen,Derek R. Lovley,Jun Yao +8 more
TL;DR: Thin-film devices made from nanometre-scale protein wires harvested from the microbe Geobacter sulfurreducens can generate continuous electric power in the ambient environment, demonstrating the feasibility of a continuous energy-harvesting strategy that is less restricted by location or environmental conditions than other sustainable approaches.
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Recent advances in implicit solvent based methods for biomolecular simulations
TL;DR: The development of constant pH molecular dynamics methods, which have recently been applied to the calculations of protein pK(a) values and the studies of pH-dependent peptide and protein folding, are presented.
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Implicit modeling of nonpolar solvation for simulating protein folding and conformational transitions.
Jianhan Chen,Charles L. Brooks +1 more
TL;DR: It is argued that, to improve beyond current level of accuracy of implicit solvent models, two important aspects of nonpolar solvation need to be incorporated, namely, the length-scale dependence of hydrophobic association and solvent screening of solute-solute dispersion interactions.
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Can molecular dynamics simulations provide high-resolution refinement of protein structure?
Jianhan Chen,Charles L. Brooks +1 more
TL;DR: Improvement can be quite reliably achieved when the initial models are sufficiently close to the native basin (e.g., 3–4 Å Cα RMSD) and reliable structural information is incorporated into the simulation protocol.