J
Jianhua He
Researcher at Kanazawa Medical University
Publications - 5
Citations - 650
Jianhua He is an academic researcher from Kanazawa Medical University. The author has contributed to research in topics: Endothelial stem cell & microRNA. The author has an hindex of 5, co-authored 5 publications receiving 557 citations.
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Journal ArticleDOI
Linagliptin-mediated DPP-4 inhibition ameliorates kidney fibrosis in streptozotocin-induced diabetic mice by inhibiting endothelial-to-mesenchymal transition in a therapeutic regimen
Keizo Kanasaki,Sen Shi,Megumi Kanasaki,Jianhua He,Takako Nagai,Yuka Nakamura,Yasuhito Ishigaki,Munehiro Kitada,Swayam Prakash Srivastava,Daisuke Koya +9 more
TL;DR: It is found that the DPP-4 inhibitor linagliptin ameliorated kidney fibrosis in diabetic mice without altering the blood glucose levels associated with the inhibition of EndMT and the restoration of microRNA 29s.
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Role of the endothelial-to-mesenchymal transition in renal fibrosis of chronic kidney disease
TL;DR: Evidence supporting the important role of EndMT in the development of renal fibrosis in CKD and its underlying mechanisms is highlighted, including novel biological significance of microRNA regulation.
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Interactions of DPP-4 and integrin β1 influences endothelial-to-mesenchymal transition
Sen Shi,Swayam Prakash Srivastava,Megumi Kanasaki,Jianhua He,Munehiro Kitada,Takako Nagai,Kyoko Nitta,Susumu Takagi,Keizo Kanasaki,Daisuke Koya +9 more
TL;DR: In this article, the DPP-4 inhibitor linagliptin was shown to improve kidney fibrosis and reduce plasma cystatin C levels in diabetic nephropathy mice.
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Effect of Antifibrotic MicroRNAs Crosstalk on the Action of N-acetyl-seryl-aspartyl-lysyl-proline in Diabetes-related Kidney Fibrosis.
Swayam Prakash Srivastava,Sen Shi,Megumi Kanasaki,Takako Nagai,Munehiro Kitada,Jianhua He,Yuka Nakamura,Yasuhito Ishigaki,Keizo Kanasaki,Daisuke Koya +9 more
TL;DR: Insight is provided into the physiologically relevant antifibrotic actions of AcSDKP via antif Bibrotic miRs; restoring such antifIBrotic programs could demonstrate potential utility in combating kidney fibrosis in diabetes.
Journal ArticleDOI
Ketogenic essential amino acids replacement diet ameliorated hepatosteatosis with altering autophagy-associated molecules
Ling Xu,Megumi Kanasaki,Megumi Kanasaki,Jianhua He,Munehiro Kitada,Kenji Nagao,Hiroko Jinzu,Yasushi Noguchi,Hiroshi Maegawa,Keizo Kanasaki,Daisuke Koya +10 more
TL;DR: The intervention study revealed that a KAA-replacement diet also ameliorated all the established metabolic and autophagy defects in the HFD-fed mice, suggesting that the diet can be used therapeutically in established diseases.