Showing papers in "Kidney International in 2015"

TL;DR: The global prevalence and absolute burden of CKD in 2010 was estimated by pooling data from population-based studies by searching MEDLINE (January 1990 to December 2014), International Society of Nephrology Global Outreach Program funded projects, and bibliographies of retrieved articles and selected 33 studies reporting gender- and age-specific prevalence in representative population samples.

TL;DR: The definition of AKI and its use in practice for clinicians and laboratory scientists are discussed and the use of electronic alerts to warn clinicians of possible AKI is enabled.

TL;DR: This review summarized areas of consensus, gaps in knowledge, and research and health-care priorities related to diagnosis; monitoring of kidney disease progression; management of hypertension, renal function decline and complications; end-stage renal disease; extrarenal complications; and practical integrated patient support that are summarized in this review.

TL;DR: The KDIGO Controversies Conference on Supportive Care in CKD reviewed the current state of knowledge in order to define a roadmap to guide clinical and research activities focused on improving the outcomes of people living with advanced CKD, including those on dialysis.

TL;DR: The team documented a plateau and decline in incidence rates, a 28% decline in death rates since 2001, and changes under the 2011 Prospective Payment System with expanded bundled payments for each dialysis treatment.

TL;DR: This review addresses the pathologic and clinical features of MGRS lesions, indications of renal biopsy, and a proposed algorithm for the hematologic workup.

TL;DR: A 2-year analysis found that the earlier clinical benefits achieved by eculizumab treatment of aHUS were maintained at 2 years of follow-up.

TL;DR: The various types of information from the ANZDATA Registry are used in a wide variety of areas, including health services planning, safety and quality programs, and clinical research projects.

TL;DR: Mitochondrial reactive oxygen species (ROS) and Nlrp3-inflammasome activation in non-myeloid-derived cells aggravate diabetic nephropathy, and targeting the inflammasomes may be a potential therapeutic approach to diabetic neophropathy.

TL;DR: Findings are of practical clinical interest, as cold ischemia time is among one of the main modifiable pre-transplantation risk factors that can be minimized by improved management of the peri-trans transplantation period.

TL;DR: Current knowledge on the origin of scar-producing myofibroblasts and cellular events triggering fibrosis are discussed.

TL;DR: It is illustrated that anti-viral pathways may be an important inducer of kidney disease in individuals with the APOL1 high-risk genotype and identifies potential targets for prevention or treatment.

TL;DR: An updated, extended UK registry analysis is presented showing that longer-term transplant outcomes in DCD donor kidneys are also similar to those for DBD donor kidneys, and that transplant outcomes for kidneys from expanded-criteria DCD donors are no less favorable than for expanded-Criteria DBD donors.

TL;DR: Adopting a new terminology for this group of diseases using the term 'Autosomal Dominant Tubulointerstitial Kidney Disease' (ADTKD) appended by a gene-based subclassification, and suggests diagnostic criteria is anticipated to facilitate recognition and characterization of these monogenic diseases.

TL;DR: This review explores the secular trends in AKI incidence in North America and Western Europe and its potential contributors and explores the impact of changes in coding and reimbursement.

TL;DR: A 12-center open-label pilot trial of critically ill adults with volume replete severe AKI of patients randomized to accelerated or standard RRT initiation, finding the findings can inform the design of a large-scale effectiveness randomized control trial.

TL;DR: The “Intestinal Immune Network for IgA Production” emerged as one of the new targets for potential therapeutic intervention and is placed in the context of the multi-hit pathogenesis model and existing knowledge of IgA immunobiology.

TL;DR: This KDIGO conference addressed a number of controversial areas in the management of DM patients with CKD, including aspects of screening for CKD with measurements of albuminuria and estimated glomerular filtration rate.

TL;DR: Sodium-MRI quantitatively detects sodium stored in skin and muscle in humans and allows studying sodium storage reduction in ESRD patients, and age and VEGF-C-related local tissue-specific clearance mechanisms may determine the efficacy of tissue sodium removal with HD.

TL;DR: Potential mechanisms of action and efficacy of probiotics as a new CKD management tool, with a particular emphasis on uremic toxin production and inflammation are outlined.

TL;DR: DGF remains an important risk factor for BPAR in a contemporary cohort of kidney transplant recipients and interventions to reduce the risk of DGF and/or its aftereffects remain of paramount importance to improve kidney transplant outcomes.

TL;DR: In high-risk patients with type II diabetes, mild and moderate CKD is associated with increased cardiovascular risk, and intensive glycemic control significantly increases the risk of cardiovascular and all-cause mortality in this population.

TL;DR: Adjusted Cox regression was used to analyze associations between IV iron dose and clinical outcomes in hemodialysis patients in 12 countries from 2002 to 2011 and found hospitalization risk was elevated among patients receiving 300 mg/month or more, and the safety of different IV iron-dosing strategies in HD patients is urgently needed.

TL;DR: In this article, the authors found that intravenous iron therapy is associated with an increased risk of serious adverse events, including those from cardiovascular causes and infectious diseases, including 36 serious cardiovascular events among 19 participants assigned to the oral iron treatment group and 55 events among 17 participants of the intravenous IR group.

TL;DR: In this article, the authors investigated the effect of PTx on survival in maintenance hemodialysis patients with severe secondary hyperparathyroidism (SHPT) and found that successful PTx may reduce the risk for all-cause and cardiovascular mortality in patients with uncontrolled SHPT.

TL;DR: The nephrotoxic potential of both dual and triple combinations of NSAIDs with renin-angiotensin system inhibitors and/or diuretics yields a higher incidence of AKI than previously thought.

TL;DR: Initial HN treatment often uses maneuvers of limited efficacy, and most patients with HN are discharged from hospital still hyponatremic, so studies to assess short- and long-term benefits of correction of HN with effective therapies are needed.

TL;DR: This review describes the expression of the TNFRs, the signaling pathways induced by them and the biological responses of TNF and its receptors in various animal models of renal diseases, and discusses the current outcomes from use of T NF biologics and TNF biomarkers in renal disorders.

TL;DR: Linkage between comorbidity burden and adverse clinical outcomes (mortality, hospitalization or myocardial infarction) was examined over median follow-up of 48 months and it was found that discordantComorbidities and mental health conditions as well as concordant comerbidities are important independent drivers of the adverse outcomes associated with CKD.