S
Swayam Prakash Srivastava
Researcher at Yale University
Publications - 54
Citations - 2343
Swayam Prakash Srivastava is an academic researcher from Yale University. The author has contributed to research in topics: Fibrosis & Diabetes mellitus. The author has an hindex of 25, co-authored 52 publications receiving 1712 citations. Previous affiliations of Swayam Prakash Srivastava include Central Drug Research Institute & Kanazawa Medical University.
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Journal ArticleDOI
Linagliptin-mediated DPP-4 inhibition ameliorates kidney fibrosis in streptozotocin-induced diabetic mice by inhibiting endothelial-to-mesenchymal transition in a therapeutic regimen
Keizo Kanasaki,Sen Shi,Megumi Kanasaki,Jianhua He,Takako Nagai,Yuka Nakamura,Yasuhito Ishigaki,Munehiro Kitada,Swayam Prakash Srivastava,Daisuke Koya +9 more
TL;DR: It is found that the DPP-4 inhibitor linagliptin ameliorated kidney fibrosis in diabetic mice without altering the blood glucose levels associated with the inhibition of EndMT and the restoration of microRNA 29s.
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Interactions of DPP-4 and integrin β1 influences endothelial-to-mesenchymal transition
Sen Shi,Swayam Prakash Srivastava,Megumi Kanasaki,Jianhua He,Munehiro Kitada,Takako Nagai,Kyoko Nitta,Susumu Takagi,Keizo Kanasaki,Daisuke Koya +9 more
TL;DR: In this article, the DPP-4 inhibitor linagliptin was shown to improve kidney fibrosis and reduce plasma cystatin C levels in diabetic nephropathy mice.
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Healing potential of Calotropis procera on dermal wounds in Guinea pigs.
A.M. Rasik,Ram Raghubir,Asheesh Gupta,Arti Shukla,Mangal P. Dubey,Swayam Prakash Srivastava,H.K Jain,D.K. Kulshrestha +7 more
TL;DR: The present study provides a scientific rationale for the traditional use of this plant in the management of wound healing by markedly increasing collagen, DNA and protein synthesis and epithelisation leading to reduction in wound area.
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MicroRNAs in Kidney Fibrosis and Diabetic Nephropathy: Roles on EMT and EndMT
TL;DR: This review highlights recent advances on the role of miRNAs in the kidney diseases; diabetic nephropathy especially focused on EMT and EndMT program responsible for the development of kidney fibrosis.
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miR-29a levels are elevated in the db/db mice liver and its overexpression leads to attenuation of insulin action on PEPCK gene expression in HepG2 cells.
Amit Kumar Pandey,Gaurav Verma,Saurabh Vig,Swayam Prakash Srivastava,Arvind K. Srivastava,Malabika Datta +5 more
TL;DR: The results, for the first time, show the effect of miR-29a in counteracting insulin action on PEPCK gene expression by primarily targeting PI3K and abrogating downstream insulin signaling in HepG2 cells.