J
Jianjun Yu
Researcher at University of Michigan
Publications - 34
Citations - 13070
Jianjun Yu is an academic researcher from University of Michigan. The author has contributed to research in topics: Prostate cancer & Cancer. The author has an hindex of 24, co-authored 26 publications receiving 11684 citations. Previous affiliations of Jianjun Yu include Northwestern University.
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Journal ArticleDOI
ONCOMINE: A Cancer Microarray Database and Integrated Data-Mining Platform
Daniel R. Rhodes,Jianjun Yu,K. Shanker,Nandan P. Deshpande,Radhika Varambally,Debashis Ghosh,Terrence R. Barrette,Akhilesh Pandey,Arul M. Chinnaiyan +8 more
TL;DR: ONCOMINE is presented, a cancer microarray database and web-based data-mining platform aimed at facilitating discovery from genome-wide expression analyses and novel biomarkers and therapeutic targets are discovered.
Journal ArticleDOI
TEAD mediates YAP-dependent gene induction and growth control
Bin Zhao,Xin Ye,Jindan Yu,Li Li,Li Li,Weiquan Li,Siming Li,Jianjun Yu,Jiandie D. Lin,Cun-Yu Wang,Arul M. Chinnaiyan,Zhi Chun Lai,Kun-Liang Guan +12 more
TL;DR: TEAD is revealed as a new component in the Hippo pathway playing essential roles in mediating biological functions of YAP, and is required for YAP-induced cell growth, oncogenic transformation, and epithelial-mesenchymal transition.
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Oncomine 3.0: genes, pathways, and networks in a collection of 18,000 cancer gene expression profiles.
Daniel R. Rhodes,Shanker Kalyana-Sundaram,Vasudeva Mahavisno,Radhika Varambally,Jianjun Yu,Benjamin B. Briggs,Terrence R. Barrette,Matthew J. Anstet,Colleen Kincead-Beal,Prakash Kulkarni,Sooryanaryana Varambally,Debashis Ghosh,Arul M. Chinnaiyan +12 more
TL;DR: Oncomine, a bioinformatics initiative aimed at collecting, standardizing, analyzing, and delivering cancer transcriptome data to the biomedical research community, provides an update on the initiative, describes the database and analysis modules, and highlight several notable observations.
Journal ArticleDOI
Large-scale meta-analysis of cancer microarray data identifies common transcriptional profiles of neoplastic transformation and progression.
Daniel R. Rhodes,Jianjun Yu,K. Shanker,Nandan P. Deshpande,Radhika Varambally,Debashis Ghosh,Terrence R. Barrette,Akhilesh Pandey,Arul M. Chinnaiyan +8 more
TL;DR: A common transcriptional profile is characterized that is universally activated in most cancer types relative to the normal tissues from which they arose, likely reflecting essential transcriptional features of neoplastic transformation.
Journal ArticleDOI
An Integrated Network of Androgen Receptor, Polycomb, and TMPRSS2-ERG Gene Fusions in Prostate Cancer Progression
Jindan Yu,Jianjun Yu,Ram Shankar Mani,Qi Cao,Chad Brenner,Xuhong Cao,Xiaoju Wang,Longtao Wu,James Li,Ming Hu,Yusong Gong,Hong Cheng,Bharathi Laxman,Adaikkalam Vellaichamy,Sunita Shankar,Yong Li,Saravana M. Dhanasekaran,Roger Morey,Terrence R. Barrette,Robert J. Lonigro,Scott A. Tomlins,Sooryanarayana Varambally,Zhaohui S. Qin,Arul M. Chinnaiyan +23 more
TL;DR: These findings provide a working model in which TMPRSS2-ERG plays a critical role in cancer progression by disrupting lineage-specific differentiation of the prostate and potentiating the EZH2-mediated dedifferentiation program.