Jiannis Ragoussis

TL;DR: This study of the epidermal differentiation complex at 1q21 provides a further example of a gene-dense complex capable of assuming extraterritorial positioning in relation to cell type/transcription status.

TL;DR: Compared with human, this larger mouse serpin repertoire probably reflects the need to regulate a larger proteinase repertoire arising from differing evolutionary pressures on the reproductive and immune systems.

TL;DR: Eight previously well-characterized and mapped probes derived from the human major histocompatibility complex (MHC) class II region were used to investigate the advantages and limitations of fluorescence in situ hybridization (FISH) techniques for fine mapping.

TL;DR: A new gene (PI8L1) at 6p25 is identified that is 72% identical to the 18q21 gene PI8, and it is proposed that the ov-serpin gene clusters arose via interchromosomal duplication of PI5 (or a precursor to 6p 25, followed by duplication at 6 p25, and a more recent interchromOSomal duplication from 7p25 to 18q to yield PI8.

TL;DR: Results presented here suggest that HCT can effectively block both ligand-induced and constitutive expression of AMF associated with high HER2 overexpression, implying a role of the AMF pathway in the action of HCT.