J
Jiaxi Wu
Researcher at University of Texas Southwestern Medical Center
Publications - 18
Citations - 10045
Jiaxi Wu is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Cyclic GMP-AMP synthase & Stimulator of interferon genes. The author has an hindex of 11, co-authored 14 publications receiving 7635 citations. Previous affiliations of Jiaxi Wu include Chinese Academy of Sciences.
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Journal ArticleDOI
Cyclic GMP-AMP Synthase is a Cytosolic DNA Sensor that Activates the Type-I Interferon Pathway
TL;DR: Results indicate that cGAS is a cytosolic DNA sensor that induces interferons by producing the second messenger cGAMP, which belongs to the nucleotidyltransferase family.
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Cyclic-GMP-AMP Is An Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA
TL;DR: Cytosolic DNA induces type I interferons and other cytokines that are important for antimicrobial defense but can also result in autoimmunity, and cGAMP functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolicDNA.
Journal ArticleDOI
Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation
Siqi Liu,Xin Cai,Jiaxi Wu,Qian Cong,Xiang Chen,Tuo Li,Fenghe Du,Junyao Ren,You Tong Wu,Nick V. Grishin,Zhijian J. Chen +10 more
TL;DR: A common signaling mechanism used by all three types of innate immune receptor-adaptor protein pairs to activate IRF3 and generate IFNs is reported, which is important because cells must regulate their IFN production carefully to avoid inflammation and autoimmunity.
Journal ArticleDOI
Innate Immune Sensing and Signaling of Cytosolic Nucleic Acids
Jiaxi Wu,Zhijian J. Chen +1 more
TL;DR: Recent advances in understanding the mechanism of nucleic acid sensing and signaling in the cytosol of mammalian cells as well as the emerging role of cytosolic nucleic acids in autoimmunity are reviewed.
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Pivotal Roles of cGAS-cGAMP Signaling in Antiviral Defense and Immune Adjuvant Effects
TL;DR: Cells from cGAS-deficient mice, including fibroblasts, macrophages, and dendritic cells, failed to produce type I interferons and other cytokines in response to DNA transfection or DNA virus infection, and were more susceptible to lethal infection with herpes simplex virus 1 than wild-type mice.