Y
You Tong Wu
Researcher at University of Texas Southwestern Medical Center
Publications - 3
Citations - 2260
You Tong Wu is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Stimulator of interferon genes & IRF3. The author has an hindex of 3, co-authored 3 publications receiving 1733 citations.
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Journal ArticleDOI
Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation
Siqi Liu,Xin Cai,Jiaxi Wu,Qian Cong,Xiang Chen,Tuo Li,Fenghe Du,Junyao Ren,You Tong Wu,Nick V. Grishin,Zhijian J. Chen +10 more
TL;DR: A common signaling mechanism used by all three types of innate immune receptor-adaptor protein pairs to activate IRF3 and generate IFNs is reported, which is important because cells must regulate their IFN production carefully to avoid inflammation and autoimmunity.
Journal ArticleDOI
Cyclic GMP-AMP Synthase Is an Innate Immune Sensor of HIV and Other Retroviruses
Daxing Gao,Jiaxi Wu,You Tong Wu,Fenghe Du,Chukwuemika Aroh,Nan Yan,Lijun Sun,Zhijian J. Chen +7 more
TL;DR: Results indicate that cGAS is an innate immune sensor of HIV and other retroviruses, suggesting that the reverse-transcribed HIV DNA triggers the innate immune response.
Journal ArticleDOI
MAVS recruits multiple ubiquitin E3 ligases to activate antiviral signaling cascades
TL;DR: It is shown that MAVS polymers recruit several TRAF proteins, including TRAF2, TRAF5, and TRAF6, through distinct TRAF-binding motifs, and that TRAF 2, 5, and 6 play a crucial role in IRF3 activation in antiviral immune responses.