C
Chuo Chen
Researcher at University of Texas Southwestern Medical Center
Publications - 100
Citations - 8616
Chuo Chen is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Catalysis & Wnt signaling pathway. The author has an hindex of 36, co-authored 97 publications receiving 7301 citations. Previous affiliations of Chuo Chen include Harvard University & National Taiwan University.
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Cyclic-GMP-AMP Is An Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA
TL;DR: Cytosolic DNA induces type I interferons and other cytokines that are important for antimicrobial defense but can also result in autoimmunity, and cGAMP functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolicDNA.
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Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer
Baozhi Chen,Michael E. Dodge,Wei Tang,Jianming Lu,Zhiqiang Ma,Chih Wei Fan,Shuguang Wei,Wayne Hao,Jessica A. Kilgore,Noelle S. Williams,Michael G. Roth,James F. Amatruda,Chuo Chen,Lawrence G. Lum +13 more
TL;DR: Two novel classes of small molecules are discovered that disrupt Wnt pathway responses and contribute to Wnt-independent signal transduction pathways and thus could be broadly exploited for chemical genetics and therapeutic goals.
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Cyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is An Endogenous High-Affinity Ligand for STING.
TL;DR: The crystal structure of STING bound to 2'3'-cGAMP revealed the structural basis of this high-affinity binding and a ligand-induced conformational change in STING that may underlie its activation, and showed that endogenous cGAMP in mammalian cells contains two distinct phosphodiester linkages.
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Label-free detection of small-molecule–protein interactions by using nanowire nanosensors
TL;DR: It is demonstrated that the silicon nanowire devices can readily and rapidly distinguish the affinities of distinct small-molecule inhibitors and, thus, could serve as a technology platform for drug discovery.
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Visible Light-Promoted Metal-Free C–H Activation: Diarylketone-Catalyzed Selective Benzylic Mono- and Difluorination
Ji-Bao Xia,Chen Zhu,Chuo Chen +2 more
TL;DR: It is shown that visible light can activate diarylketones to abstract a benzylic hydrogen atom selectively and the scope and efficiency of this new C-H fluorination method are significantly better than those of the existing methods.